A new method for controlling structural, electrical and optical properties of phosphate glasses, containing transition metal ions (TMIs)

Karimi, Majid Bigdeli; Mehdizadeh, Ali; Hekmatshoar, Mohammad Hossein; Vafaei, Samira

doi:10.1016/j.jnoncrysol.2019.119693

Cited by 10 publications

(1 citation statement)

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“…The addition of transition metal oxides (TMOs) in the composition of phosphate glass typically leads to the depolymerization of the vitreous phosphate network and to the formation of new P–O–TM bonds [ 13 ]. These structural modifications are linked to the amount of doping and have a strong influence on the physical, chemical, and magnetic properties of these glasses [ 19 , 20 , 21 , 22 ]. Moreover, including TMOs in the P 2 O 5 network not only improves their properties but can also have beneficial effects from a biological perspective [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Studies Demonstrate Antitumor Activity of Vanadium Ions from a CaO-P2O5-CaF2:V2O5 Glass System in Human Cancer Cell Lines A375, A2780, and Caco-2

Lujerdean

Zăhan

Dezmirean

et al. 2023

IJMS

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In this research, we investigated the structural and biological properties of phosphate glasses (PGs) after the addition of V2O5. A xV2O5∙(100 − x)[CaF2∙3P2O5∙CaO] glass system with 0 ≤ x ≤ 16 mol% was synthesized via a conventional melt-quenching technique. Several analysis techniques (dissolution tests, pH, SEM-EDS, FT-IR, and EPR) were used to obtain new experimental data regarding the structural behavior of the system. In vitro tests were conducted to assess the antitumor character of V2O5-doped glass (x = 16 mol%) compared to the matrix (x = 0 mol%) and control (CTRL-) using several tumoral cell lines (A375, A2780, and Caco-2). The characterization of PGs showed an overall dissolution rate of over 90% for all vitreous samples (M and V1–V7) and the high reactivity of this system. EPR revealed a well-resolved hyperfine structure (hfs) typical of vanadyl ions in a C4v symmetry. FT-IR spectra showed the presence of all structural units expected for P2O5, as well as very clear depolymerization of the vitreous network induced by V2O5. The MTT assay indicated that the viability of tumor cells treated with V7-glass extract was reduced to 50% when the highest concentration was used (10 µg/mL) compared to the matrix treatment (which showed no cytotoxic effect at any concentration). Moreover, the matrix treatment (without V2O5) provided an optimal environment for tumor cell attachment and proliferation. In conclusion, the two types of treatment investigated herein were proven to be very different from a statistical point of view (p < 0.01), and the in vitro studies clearly underline the cytotoxic potential of vanadium ions from phosphate glass (V7) as an antitumor agent.

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