CONCLUSION: P-GW is useful for achieving selective biliary cannulation. Pancreatic duct stenting after P-GW can reduce the incidence of post-ERCP pancreatitis, which requires evaluation by means of prospective randomized controlled trials.
INTRODUCTIONEndoscopic retrograde cholangio-pancreatography (ERCP), which was first reported in the late 1960's [1] , is a well-accepted technique for evaluating pancreatobiliary diseases. Although selective cannulation of the bile duct is mandatory for therapeutic ERCP of biliary diseases, anatomical difficulties or papillary spasm sometimes preclude it. Numerous techniques have been developed for selective biliary cannulation [2,3] . Pancreatic guidewire placement (P-GW) has been reported to be effective in patients with difficult cannulation of the bile duct [4][5][6][7] . Since P-GW is usually attempted in patients with difficult cannulation of the bile duct, this technique entails a possible increased risk of post-ERCP pancreatitis. The aim of this study was to investigate the frequency and risk factors for acute pancreatitis after P-GW in achieving cannulation of the bile duct during ERCP. Abstract AIM: To investigate the frequency and risk factors for acute pancreatitis after pancreatic guidewire placement (P-GW) in achieving cannulation of the bile duct during endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: P-GW was performed in 113 patients in whom cannulation of the bile duct was difficult. The success rate of biliary cannulation, the frequency and risk factors of post-ERCP pancreatitis, and the frequency of spontaneous migration of the pancreatic duct stent were investigated. RESULTS: Selective biliary cannulation with P-GW was achieved in 73% of the patients. Post-ERCP pancreatitis occurred in 12% (14 patients: mild, 13; moderate, 1). Prophylactic pancreatic stenting was attempted in 59% of the patients. Of the 64 patients who successfully underwent stent placement, three developed mild pancreatitis (4.7%). Of the 49 patients without stent placement, 11 developed pancreatitis (22%: mild, 10; moderate, 1). Of the five patients in whom stent placement was unsuccessful, two developed mild pancreatitis. Univariate and multivariate analyses revealed no pancreatic stenting to be the only significant risk factor for pancreatitis. Spontaneous migration of the stent was observed within two weeks in 92% of the patients who had undergone pancreatic duct stenting.