A new method for pH triggered curcumin release by applying poly(l-lysine) mediated nanoparticle-congregation

Patra, Digambara; Sleem, Fatima

doi:10.1016/j.aca.2013.07.063

Cited by 54 publications

(32 citation statements)

References 64 publications

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“…ca. 4 ppb (4 μg/L at pH = 7,3) [44]. Curcuminoids were the best extracted by CCMA-H 2 O (1:1:3), 0.355 ± 0.019 mg/g, which is in agreement with that reported by Euterpio et al [35] and Kwon and Chung [45].…”

Section: Hnuclear Overhauser Enhancement Spectroscopy (Noesy) It Revsupporting

confidence: 90%

Green Separation of Bioactive Natural Products Using Liquefied Mixture of Solids

Zullaikah¹,

Rachmaniah²,

Utomo³

et al. 2018

Green Chemistry

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Bioactive natural products are secondary metabolites of plants and animals generated through various biological pathways. They are the main sources of new drugs, functional food and food additives. Since their contents in plant and animal tissues are extremely small compared to those of primary metabolites, the separations of bioactive principles from complex matrixes are often the inherent bottleneck in the utilization of bioactive natural products. A novel separation technique based on a liquefied mixture of solids at its eutectic compositions is presented in this chapter. The mixture can be prepared from natural primary metabolites and therefore can be considered as a green solvent. The separation of bioactive compounds (γ-oryzanol) from rice bran oil-based biodiesel using green methods with minimum energy requirement is discussed. Other applications for separations of alkaloid and phenolic compounds from their plant matrices are also presented. Different raw materials require different separation techniques due to the presence of different impurities, and the current trend is to use green methods with minimum energy requirement. This overview of recent technological advances, discussion of pertinent problems and prospect of current methodologies in the separation of bioactive natural products may provide a driving force for the development of novel separation techniques.

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Section: Hnuclear Overhauser Enhancement Spectroscopy (Noesy) It Revsupporting

confidence: 90%

Green Separation of Bioactive Natural Products Using Liquefied Mixture of Solids

Zullaikah¹,

Rachmaniah²,

Utomo³

et al. 2018

Green Chemistry

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“…In Figure S6e–h, the condensed and/or fragmented nuclei are marked by arrows, providing the evidence of cell death33. Cur molecules were thus efficiently released from complexes distributed in cells because of the acidic environment (pH 5.0)31. Consequently, the graphene derivative-Cur complexes accumulated in cells may have enabled continuous Cur release in cancer cells, ensuring sufficient Cur accumulation in order to achieve adequate concentration to continually kill cancer cells14.…”

Section: Resultsmentioning

confidence: 96%

“…The concentration of the released Cur was determined by measuring free Cur. In particular, Cur molecules stacked on graphene derivatives remained stable in basic and near neutral buffers in which about ~9.8% to ~5% Cur was released from graphene derivatives at pH 7.5 or 9 in 24 h, respectively31. In sharp contrast, as much as ~85% of Cur was released from graphene derivatives after 24 h at ~pH 5 (Figure 4d) due to protonation and subsequent reduced interaction between Cur and graphene derivatives in acidic environments.…”

Section: Resultsmentioning

confidence: 98%

Cancer Therapy Using Ultrahigh Hydrophobic Drug-Loaded Graphene Derivatives

Some

Gwon

Hwang

et al. 2014

Sci Rep

112

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This study aimed to demonstrate that curcumin (Cur)-containing graphene composites have high anticancer activity. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug Cur based on pH dependence. Different Cur-graphene composites were prepared based on polar interactions between Cur and the number of oxygen-containing functional groups of respective starting materials. The degree of drug-loading was found to be increased by increasing the number of oxygen-containing functional groups in graphene-derivatives. We demonstrated a synergistic effect of Cur-graphene composites on cancer cell death (HCT 116) both in vitro and in vivo. As-prepared graphene quantum dot (GQD)-Cur composites contained the highest amount of Cur nano-particles and exhibited the best anticancer activity compared to the other composites including Cur alone at the same dose. This is the first example of synergistic chemotherapy using GQD-Cur composites simultaneous with superficial bioprobes for tumor imaging.

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“…3B) obtained for the curcumin loaded CD-MOFs crystals dispersed in methanol is identical to that of curcumin in methanol, thus, the interaction between curcumin and the CD-MOFs crystals preserves the photo-physical properties of curcumin. Curcumin has been shown to be a good probe molecule to sense the local environment of heterogeneous systems (Gogoi & Sen Sarma, 2015;Patra & Sleem, 2013). The fluorescence spectra for curcumin encapsulated CD-MOFs and the supernatant washed off curcumin-loaded CD-MOFs were found to be similar and showed a negligible blue shift compared to curcumin in methanol.…”

Section: Spectroscopic Studymentioning

confidence: 96%

Encapsulation of curcumin in cyclodextrin-metal organic frameworks: Dissociation of loaded CD-MOFs enhances stability of curcumin

et al. 2016

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A new method for pH triggered curcumin release by applying poly(l-lysine) mediated nanoparticle-congregation

Cited by 54 publications

References 64 publications

Green Separation of Bioactive Natural Products Using Liquefied Mixture of Solids

Green Separation of Bioactive Natural Products Using Liquefied Mixture of Solids

Cancer Therapy Using Ultrahigh Hydrophobic Drug-Loaded Graphene Derivatives

Encapsulation of curcumin in cyclodextrin-metal organic frameworks: Dissociation of loaded CD-MOFs enhances stability of curcumin

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