A New Method for Quantification and Assessment of Epileptiform Activity in EEG with Special Reference to Focal Nocturnal Epileptiform Activity

Larsson, Pål G.; Wilson, John; Eeg‐Olofsson, Orvar

doi:10.1007/s10548-008-0072-3

Cited by 35 publications

(31 citation statements)

References 163 publications

(204 reference statements)

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“…FNEA was defined as sleep enhanced focal epileptiform activity with a spike index above 30 (Larsson et al 2009). From this group of patients, 30 fulfilling the following criteria were identified and included in the study: The patients should have been subject to two separate EEG recordings, one before (pre-LEV) and one after (in-LEV) introduction of levetiracetam (LEV), and they should be on LEV monotherapy during the in-LEV investigation.…”

Section: Methodsmentioning

confidence: 99%

Decrease in Propagation of Interictal Epileptiform Activity After Introduction of Levetiracetam Visualized with Electric Source Imaging

et al. 2010

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Different neuroimaging techniques (fMRI, spectroscopy, PET) are being used to evaluate candidate drugs in pharmacological development. In patients with epilepsy fast propagation of the epileptiform activity between different brain areas occurs. Electric Source Imaging (ESI), in contrast to the aforementioned techniques, has a millisecond time resolution, allowing visualization of this fast propagation. The purpose of the current project was to use ESI to investigate whether introduction of an antiepileptic drug (levetiracetam, LEV) would change the propagation patterns of the interictal epileptiform activity. Thirty patients with epilepsy were subject to an EEG recording before (pre-LEV) and after (in-LEV) introduction of LEV. Interictal spikes with similar topographic distribution were averaged within each subject, and a distributed source model was used to localize the EEG sources of the epileptiform activity. The temporal development of the activity within 20 regions of interest (ROIs) was determined, and source propagation between different regions was compared between the pre-LEV and in-LEV recordings. Patients with epileptic seizures showed propagation in 22/24 identified spike types in the pre-LEV recordings. In the in-LEV recordings only 7/15 spike types showed propagation, and six of these seven propagating spikes were recorded in patients with poor effect of treatment. Also in patients without seizures LEV tended to suppress propagation. We conclude that the observed suppression of source propagation can be considered as an indicator of effective antiepileptic treatment. ESI might thus become a useful tool in the early clinical evaluation of new candidate drugs in pharmacological development.

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Section: Methodsmentioning

confidence: 99%

Decrease in Propagation of Interictal Epileptiform Activity After Introduction of Levetiracetam Visualized with Electric Source Imaging

et al. 2010

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“…Computation of the SWI was performed only by using semiautomated spike search based on template matching, 28 the reliability of which in comparison to visual scoring was previously tested at the Danish Epilepsy Center. Recognizing that the EEG focus is only an approximation of the anatomic substrate, we call the assigned electrodes "epileptic focus" for practical reasons.…”

Section: Epileptic Focus and Swimentioning

confidence: 99%

“…Recognizing that the EEG focus is only an approximation of the anatomic substrate, we call the assigned electrodes "epileptic focus" for practical reasons. Computation of the SWI was performed only by using semiautomated spike search based on template matching, 28 the reliability of which in comparison to visual scoring was previously tested at the Danish Epilepsy Center. In our study, we refer to the mean SWI during NREM sleep over the overnight EEG recordings.…”

Section: Epileptic Focus and Swimentioning

confidence: 99%

Remission of encephalopathy with status epilepticus (ESES) during sleep renormalizes regulation of slow wave sleep

et al. 2017

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This study provides evidence that alterations of overnight changes of NREM-sleep slow waves during active ESES are reversible when ESES resolves, and that the severity of neuropsychological compromise might be related to the extent of slow wave impairment during ESES. Our findings suggest that analysis of slow waves might serve as a prognostic factor regarding cognitive outcome. ESES may serve as disease model of pathologic slow wave sleep and our results might be expanded to epilepsies with spike wave activation in slow wave sleep not only in children but also in adults.

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“…Recent developments of automated methods for seizure detection can be a step forward in providing real-time interpretation of the electroencephalogram. [23][24][25][26][27] …”

Section: Discussionmentioning

confidence: 99%

Electroencephalography in the Pediatric Emergency Department

et al. 2013

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This study aimed to identify the indications in which electroencephalography in the pediatric emergency department is most useful. We retrospectively reviewed the influence that the results of the emergent electroencephalogram had on the eventual disposition of patients at our pediatric emergency department. Sixty-eight children (mean age, 7.3 years; 32 males) underwent 70 emergent electroencephalograms. Fifty-seven emergent electroencephalograms were performed for the suspicion of ongoing seizures or status epilepticus. Thirteen of the 22 children (59.1%) discharged from the emergency department were sent home mainly based on the results of the emergent electroencephalogram, which prevented an admission. In particular, 11 of 38 children with frequent and recurrent paroxysmal events concerning for seizures and 2 of 19 children with suspected ongoing status epilepticus were discharged after excluding an epileptic disturbance. The emergent electroencephalogram provided meaningful clinical information that influenced disposition, especially in patients with ongoing events in which the clinical picture was clarified by a rapidly acquired electroencephalogram.

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A New Method for Quantification and Assessment of Epileptiform Activity in EEG with Special Reference to Focal Nocturnal Epileptiform Activity

Cited by 35 publications

References 163 publications

Decrease in Propagation of Interictal Epileptiform Activity After Introduction of Levetiracetam Visualized with Electric Source Imaging

Decrease in Propagation of Interictal Epileptiform Activity After Introduction of Levetiracetam Visualized with Electric Source Imaging

Remission of encephalopathy with status epilepticus (ESES) during sleep renormalizes regulation of slow wave sleep

Electroencephalography in the Pediatric Emergency Department

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