A New Method for Quantifying Aluminum in Antiperspirant Lotion Using a Differential Refractometer and an HPLC Column Containing a Maleate Functional Group Kumarswamy Ummiti1*, Narayana Reddy Godi2 , Hanimi Reddy Bapatu2

Abstract

Aluminum chlorohydrate is a chemical substance employed as an agent to reduce perspiration. As an active antiperspirant agent, it is present in over-the-counter hygiene products at a concentration of up to 25%. The concentration of aluminum chrohydrate will be estimated indirectly by measuring the concentration of free aluminum ions. Various methodological approaches, including atomic absorption spectroscopy, ion chromatography, and titration, can be employed for the estimation of aluminum. In this study, a novel reverse-phase isocratic liquid chromatography approach was created. The method utilized a differential refractometer, a column packed with a maleate group, and an eluent consisting of 2.0% v/v formic acid. The suggested methodology demonstrates a high degree of precision in quantifying the presence of aluminum in Aldry lotion. According to studies testing accuracy, linearity, and precision, the disclosed analytical technique for quantifying aluminum has a range of 0.125 mg/mL to 0.375 mg/mL. The proposed methodology has a significantly reduced execution time of 10 minutes and is characterized by its cost-effectiveness.