A new method for simultaneous determination of nitrogen, hydrogen and halogen in organic compounds

Kozlowski, E.; Biziuk, Marek

doi:10.1007/bf01198043

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Molecules 2024, 29, x FOR PEER REVIEW 8 of 47 deficit could be the [N(CH2R)4] + tetrasubstituted ammonium structure of the central ammonium nitrogen. Compounds of this type are known to cause combustion problems [46]. It could be speculated that the sodium content (NaCl) in salt-containing compound 1 (PENTA) led to the formation of only partially combustible sodium nitrate (NaNO3).…”

Section: The Synthesis Of Pure Compound 1 [Pt162 (Nsc 796018)]mentioning

confidence: 99%

Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells

Kesel

2024

Molecules

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I propose a new strategy to suppress human cancer completely with two entirely new drug compounds exploiting cancer’s Warburg effect characterized by a defective mitochondrial aerobic respiration, substituted by cytosolic aerobic fermentation/glycolysis of D-(+)-glucose into L-(+)-lactic acid. The two essentially new drugs, compound 1 [P(op)T(est)162] and compound 3 (PT167), represent new highly symmetric, four-bladed propeller-shaped polyammonium cations. The in vitro antineoplastic highly efficacious drug compound 3 represents a covalent combination of compound 1 and compound 2 (PT166). The intermediate drug compound 2 is an entirely new colchic(in)oid derivative synthesized from colchicine. Compound 2’s structure was determined using X-ray crystallography. Compound 1 and compound 3 were active in vitro versus 60 human cancer cell lines of the National Cancer Institute (NCI) Developmental Therapeutics Program (DTP) 60-cancer cell testing. Compound 1 and compound 3 not only stop the growth of cancer cells to ±0% (cancerostatic effect) but completely kill nearly all 60 cancer cells to a level of almost −100% (tumoricidal effect). Compound 1 and compound 3 induce mitochondrial apoptosis (under cytochrome c release) in all cancer cells tested by (re)activating (in most cancers impaired) p53 function, which results in a decrease in cancer’s dysregulated cyclin D1 and an induction of the cell cycle-halting cyclin-dependent kinase inhibitor p21Waf1/p21Cip1.

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Section: The Synthesis Of Pure Compound 1 [Pt162 (Nsc 796018)]mentioning

confidence: 99%

Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells

Kesel

2024

Molecules

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History of Polish analytical chemistry since 1945

Hulanicki

2014

Anal Bioanal Chem

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Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells

Kesel

2024

Preprint

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I propose a new strategy to suppress human cancer completely with two entirely new drug compounds exploiting cancer's Warburg effect characterized by a defective mitochondrial aerobic respiration, substituted for by cytosolic aerobic fermentation/glycolysis of D-(+)-glucose into L-(+)-lactic acid. The two essentially new drugs compound 1 [P(op)T(est)162] and compound 3 (PT167) represent new highly symmetric, four-bladed propeller-shaped polyammonium cations. The in vitro antineoplastic highly efficacious drug compound 3 represents a covalent combination of compound 1 and compound 2 (PT166). The intermediate drug compound 2 is an entirely new colchic(in)oid derivative synthesized from colchicine. Compound 2's structure was determined by X-ray crystallography. Compound 1 and compound 3 were active in vitro versus 60 human cancer cell lines of the National Cancer Institute (NCI) Developmental Therapeutics Program (DTP) 60-cancer cell testing. Compound 1 and compound 3 both not only stop the growth of cancer cells to ±0% (cancerostatic effect), but completely kill nearly all 60 cancer cells to a level of almost −100% (tumoricidal effect). Compound 1 and compound 3 induce mitochondrial apoptosis (under cytochrome c release) in all cancer cells tested by (re)activating (in most cancers impaired) p53 function which results in a decrease of cancer's dysregulated cyclin D1 and an induction of the cell cycle-halting cyclin-dependent kinase inhibitor p21Waf1/p21Cip1.

show abstract

A new method for simultaneous determination of nitrogen, hydrogen and halogen in organic compounds

Cited by 3 publications

References 12 publications

Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells

Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells

History of Polish analytical chemistry since 1945

Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells

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