A new method for the synthesis of amides from imines

Ghaffarzadeh, Mohammad; Joghan, Somaye Shahrivari; Faraji, Fereshteh

doi:10.1016/j.tetlet.2011.11.018

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…424,425 Several synthetic approaches have been developed for their Scheme construction since Janssen's rst discovery. [426][427][428][429] The approach is described herein were actually optimized to provide fentanyls in higher yields using a highly effective three-step synthetic Donepezil is the most effective inhibitor of the AChE currently accessible on the market, also sold, under the brand name Aricept. 434,435 Donepezil has been synthesized via two different pathways.…”

Section: Five-membered Heterocyclesmentioning

confidence: 99%

Prescribed drugs containing nitrogen heterocycles: an overview

2020

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Section: Five-membered Heterocyclesmentioning

confidence: 99%

Prescribed drugs containing nitrogen heterocycles: an overview

2020

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“…Ghaffarzadeh et al suggested a method for fentanyl synthesis by the reduction of Schiff base 2.22.d in the presence of propionic anhydride (Scheme ). , The reaction yielded 280 mg of the product (84%) with an RME of 26%.…”

Section: Drugs Affecting the Central Nervous Systemmentioning

confidence: 99%

Reductive Amination in the Synthesis of Pharmaceuticals

et al. 2019

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Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of the key approaches to C–N bond construction due to its operational easiness and a wide toolbox of protocols. Recent studies show that at least a quarter of C–N bond-forming reactions in the pharmaceutical industry are performed via reductive amination. This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination. Compounds are grouped according to the principle of action, which includes drugs affecting the central nervous system, drugs affecting the cardiovascular system, anticancer drugs, antibiotics, antiviral and antifungal medicines, drugs affecting the urinary system, drugs affecting the respiratory system, antidiabetic medications, drugs affecting the gastrointestinal tract, and drugs regulating metabolic processes. A general synthetic scheme is provided for each compound, and the description is focused on reductive amination steps. The green chemistry metric of reaction mass efficiency was calculated for all reactions.

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“…For instance, interesting imine intermediates 120, which are rarely reported as starting materials for coupling reactions, were em-ployed for a reductive acylation with carboxylic acid anhydride 121 (Scheme 38). 65 The TES/Zn-promoted reaction offers facile and efficient access to skeletally attractive amides 122.…”

Section: Scheme 36 Reductive Homocoupling Of Aldehydes Yielding Symmementioning

confidence: 99%

Recent Advances in the Applications of Triethylsilane in Organic Synthesis

Ručilová

Soural

2018

Synthesis

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The synthesis of pharmacologically relevant scaffolds is an important goal in modern organic chemistry. For this reason, the use of methodologies involving operationally simple procedures and easily handled reagents to chemoselectively and stereoselectively convert different functionalities has gained considerable attention. In this review, we summarize the latest trends in reductive reactions using triethylsilane as the key reagent that provide synthetically interesting intermediates, coupling products and structures with control of the 3D architecture.1 Introduction2 Scenario A: Reduction of C–C Multiple Bonds3 Scenario B: Reduction of Functional Groups4 Scenario C: Reductive Coupling5 Scenario D: Reductive Cyclization6 Conclusion

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A new method for the synthesis of amides from imines

Cited by 17 publications

References 23 publications

Prescribed drugs containing nitrogen heterocycles: an overview

Prescribed drugs containing nitrogen heterocycles: an overview

Reductive Amination in the Synthesis of Pharmaceuticals

Recent Advances in the Applications of Triethylsilane in Organic Synthesis

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