A New Method for the Prevention of Pre-Analytical Errors due to Hemolysis: Intensive Training

Yazar, Hayrullah; Yücel, Murat; Bozkurt, Berna; Pekgör, Ahmet; Kadılar, Özlem

doi:10.7754/clin.lab.2016.151224

Cited by 2 publications

(19 citation statements)

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“…The majority of the studies ( n = 6) were from Europe; Spain (Lillo et al, ; Romero et al, , ); Turkey (Yazar et al, ); Austria (Cadamuro et al, ); and Sweden (Bolenius et al, ). The remaining 2 were from Australia (Corkill, ) and Singapore (Ong, Chan, & Lim, ; Ong et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the studies ( n = 6) samples staff involved in the conduct of venepuncture. These included registered and enrolled nurses and laboratory technicians (Bolenius et al, ); junior doctors and nurses (Cadamuro et al, ); doctors and medical students (Ong et al, ); nurses and phlebotomists (Romero et al, ); nurses, physicians, auxiliary and administrative staff (Romero et al, ); and phlebotomists, nurses, paramedics and other unspecified relevant personnel (Yazar et al, ). Corkill () involved emergency department (ED) staff, with no specific details.…”

Section: Resultsmentioning

confidence: 99%

“…None of the included studies were RCTs. Five of the studies (Bolenius et al, ; Corkill, ; Cadamuro et al, ; Ong et al, ; Yazar et al, ) investigated the impact of training on a single primary outcome (haemolysis rate). Three involved multiple pre‐analytical errors (i.e., rate of clotted and insufficient samples and impact on use of quality labels) besides haemolysis rate (Lillo et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…Any delays in the provision of care due, for example, to haemolysed blood samples, can prolong hospital stay and increase costs (Ong et al, ). As in vitro blood sample haemolysis is preventable, appropriately designed and standardised processes could facilitate the reduction in haemolysis rate (Yazar et al, ). Nevertheless, for the proper handling of the equipment and successful implementation of processes, the operator requires good education and training in the conduct of venepuncture and in haemolysis prevention.…”

Section: Introductionmentioning

confidence: 99%

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The impact of venepuncture training on the reduction of pre‐analytical blood sample haemolysis rates: A systematic review

Makhumula-Nkhoma

Weston

McSherry

et al. 2019

Journal of Clinical Nursing

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Background Venepuncture involves the introduction of a needle into a vein to collect a representative blood sample for laboratory testing. In the pre‐analytical phase, haemolysis (the rupturing of erythrocytes and release of their contents into the extracellular compartment) has safety, quality and cost implications. Training in correct venepuncture practice has the potential to reduce in vitro haemolysis rates, but the evidence for this notion has yet to be synthesised. Design Systematic review (PRISMA Checklist). Methods Published studies on the effectiveness of venepuncture training on haemolysis rates were searched in relevant databases. The McMaster critical appraisal tool was used to assess methodological quality. The GRADE tool was used to evaluate the body of evidence in relation to the research questions. Implementation fidelity was also scrutinised in each study. Results Eight out of 437 retrieved studies met the inclusion criteria. None were randomised controlled trials (RCT). Between‐study heterogeneity in design, intervention characteristics and the biochemical threshold for haemolysis precluded a meta‐analysis. Post‐training reductions in haemolysis rates of between 0.4%–19.8% were reported in four of the studies, which developed their intervention according to a clear evidence base and included mentoring in the intervention. Rises in haemolysis rates of between 1.3%–1.9% were reported in two studies, while the intervention effect was inconsistent within two other studies. Conclusion There are no RCTS on the effectiveness of venepuncture training for reducing haemolysis rates, and findings from the existing uncontrolled studies are unclear. For a more robust evidence base, we recommend more RCTs with standardisation of haemolysis thresholds and training‐related factors. Relevance to clinical practice While venepuncture training is an important factor influencing quality of blood sample in clinical practice, more robust evidence is needed to make specific recommendations about training content for reduction of haemolysis rates. Standardisation of haemolysis thresholds would also enable future meta‐analyses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of venepuncture training on the reduction of pre‐analytical blood sample haemolysis rates: A systematic review

Makhumula-Nkhoma

Weston

McSherry

et al. 2019

Journal of Clinical Nursing

View full text Add to dashboard Cite

show abstract

“…The clinical supervisor of the biochemistry laboratory and specialist doctors were on the training team (intensive training method) [22]. Venous blood collection was controlled by the research team, with regard to good clinical practice, equipment and supplies, and blood collection area characteristics and site, to minimize preanalytical laboratory errors.…”

Section: Methodsmentioning

confidence: 99%

Effect of Centrifuge Temperature on Routine Coagulation Tests

2018

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Background: This study investigated the effects of cooled and standard centrifuges on the results of coagulation tests to examine the effects of centrifugation temperature. Methods: Equal-volume blood samples from each patient were collected at the same time intervals and subjected to standard (25°C) and cooled centrifugation (2–4°C). Subsequently, the prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer values were determined in runs with the same lot numbers in the same coagulation device using the Dia-PT R (PT and INR), Dia-PTT-liquid (aPTT), Dia-FIB (fibrinogen), and Dia-D-dimer kits, respectively. Results: The study enrolled 771 participants. The PT was significantly (p < 0.018) higher in participants on anticoagulant therapy. The respective median values of the test parameters determined using the standard and cooled centrifuges were as follows: PT 10.30 versus 10.50 s; PT (INR) 1.04 versus 1.09 s; APTT 28.90 versus 29.40 s; fibrinogen 321.5 versus 322.1 mg/dL; and D-dimer 179.5 versus 168.7 µg FEU/mL. There were significant differences (p < 0.001) in the parameters between the values obtained with the standard and cooled centrifuges. Conclusions: Centrifuge temperature can have a significant effect on the results of coagulation tests. However, broad and specific disease-based studies are needed.

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A New Method for the Prevention of Pre-Analytical Errors due to Hemolysis: Intensive Training

Abstract: The IT method is effective in preventing hemolysis-induced pre-analytical errors.

Cited by 2 publications

References 0 publications

The impact of venepuncture training on the reduction of pre‐analytical blood sample haemolysis rates: A systematic review

The impact of venepuncture training on the reduction of pre‐analytical blood sample haemolysis rates: A systematic review

Effect of Centrifuge Temperature on Routine Coagulation Tests

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