A New Method of Total Reconstruction of the Auricle for Microtia

Nagata, Satoru

doi:10.1097/00006534-199308000-00001

Cited by 482 publications

(285 citation statements)

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“…Surgical ear reconstruction was developed by Tanzer in the late 1950s (11), and today, the most frequently applied methods are based on the work of Brent (12) and Nagata (13). These procedures require several consecutive surgeries with the complexity of the operation varying with the size of the defect.…”

Section: Functional Outcome Of Auricular Cartilage Reconstruction Andmentioning

confidence: 99%

Quantitative Evaluation of Mechanical Properties in Tissue-Engineered Auricular Cartilage

Nimeskern

Osch

Müller

et al. 2014

Tissue Engineering Part B: Reviews

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Keywords:Auricular cartilage, elastic cartilage, auricle, pinna, outer ear, mechanical testing, elastin Conflict of interest:All authors have no conflict of interest. 3 AbstractTissue-engineering (TE) efforts for ear-reconstruction often fail due to mechanical incompetency. It is therefore key for successful auricular cartilage TE to ensure functional competency, i.e. to mimic the mechanical properties of the native ear tissue. A review of past attempts to engineer auricular cartilage shows unsatisfactory functional outcomes with various cell-seeded biodegradable polymeric scaffolds in immunocompetent animal models. However, promising improvements to construct stability were reported with either mechanically-reinforced scaffolds or novel two-stage implantation techniques. Nonetheless, quantitative mechanical evaluation of the constructs is usually overlooked, and such an evaluation of TE constructs alongside a benchmark of native auricular cartilage would allow real-time monitoring and improve functional outcomes of auricular TE strategies.Although quantitative mechanical evaluation techniques are readily available for cartilage, these techniques are designed to characterize the main functional components of hyaline and fibrous cartilage such as the collagen matrix or the glycosaminoglycan (GAG) network, but they overlook the functional role of elastin, which is a major constituent of auricular cartilage. Hence for monitoring auricular cartilage TE, novel evaluation techniques need to be designed. These should include a characterization of the specific composition and architecture of auricular cartilage, as well as mechanical evaluation of all functional components. Therefore, this paper reviews the existing literature on auricular cartilage TE as well as cartilage mechanical evaluation and proposes recommendations for designing a mechanical evaluation protocol specific for auricular cartilage, and establishing a benchmark for native auricular cartilage to be used for quantitative evaluation of TE auricular cartilage.15.02.13 4

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Section: Functional Outcome Of Auricular Cartilage Reconstruction Andmentioning

confidence: 99%

Quantitative Evaluation of Mechanical Properties in Tissue-Engineered Auricular Cartilage

Nimeskern

Osch

Müller

et al. 2014

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

show abstract

“…Cartilage donor sites include the ear cartilage itself from the ipsi-or contralateral ear, the nasal septum or rib. In cases of subtotal or total absence of the auricle, complete cartilage framework reconstruction has to be carried out using as much as the cartilaginous part of three ribs [7][8][9]. Soft tissue coverage is provided by using either local skin or a superficial temporoparietal fascial flap.…”

Section: Clinical Need Of Cartilagementioning

confidence: 99%

Bone and cartilage tissue engineering for facial reconstructive surgery

Farhadi

Jaquiéry

Haug

et al. 2006

IEEE Eng. Med. Biol. Mag.

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“…Tanzer 1 introduced the use of autologous costal cartilage and Brent 2 , Firmin and Nagata 3 refined the technique to produce consistent and high quality auricles. In microtia, the final result is highly dependent on the baseline condition of the surrounding skin.…”

Section: Location Location Locationmentioning

confidence: 99%