A new method to determine frequency characteristics of the respiratory system

Lándsér, F. J.; Nagles, J; Demedts, Maurice; Billiet, L; Woestijne, K. P. Van de

doi:10.1152/jappl.1976.41.1.101

Cited by 236 publications

(128 citation statements)

References 7 publications

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“…The changes in R and 0Zrs0 with condition were most pronounced at 1.5 Hz and had disappeared at 5 Hz. In humans, the larger change in R at low vs. high frequencies has been demonstrated after bronchial challenge (19), in asthmatic vs. normal humans (9,13), and in asthmatic subjects after bronchodilation (20). The definitions of ''high'' and ''low'' frequencies depend on the size of the animal.…”

Section: Discussionmentioning

confidence: 99%

Frequency dependence of forced oscillatory respiratory mechanics in horses with heaves

Young

Tesarowski

Viel

1997

Journal of Applied Physiology

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Young, S. S., D. Tesarowski, and L. Viel. Frequency dependence of forced oscillatory respiratory mechanics in horses with heaves. J. Appl. Physiol. 82(3): 983-987, 1997.-The effect of measurement frequency on respiratory mechanics was investigated in six horses with reversible allergic airway disease. Total respiratory impedance was measured at 1.5, 2.0, 3.0, and 5.0 Hz by using the forced oscillation technique with the horses in remission, after acute antigenic challenge producing clinical heaves, and with heaves but after the administration of 2 mg fenoterol by inhalation. The slopes of the magnitude (0Zrs0) and real part (R) of total respiratory impedance over the frequency range 1.5-3 Hz changed significantly after antigenic challenge and fenoterol. The ratio of R at 2 Hz to R at 3 Hz, however, discriminated better among the three conditions. Compliance and resonant frequency (calculated by using a three-element model) changed significantly after antigenic challenge and fenoterol, but inertance did not. We concluded that horses with heaves showed frequency dependence of R and 0Zrs0 at frequencies up to 3 Hz and that parameters derived from a three-element model were useful indicators of small airway obstruction in the horse. resistance; compliance; inertance; resonant frequency; airway obstruction THE MECHANICAL PROPERTIES of the respiratory system have been known for many years (15) to change with measurement frequency, an effect called frequency dependence. This phenomenon is much more marked in respiratory disease, particularly obstructive respiratory disease, and the subject was extensively reviewed by Cutillo and Renzetti (4). Frequency dependence of resistance has also been used to measure the response to bronchial challenge with histamine (19).The forced oscillation technique is particularly suitable for measuring changes in respiratory mechanics with frequency because it measures total respiratory impedance over a range of frequencies in a rapid, noninvasive manner. The technique is well tolerated by conscious, unsedated animals including larger species, such as cattle (5, 6) and ponies (22). We have previously shown how the forced oscillation technique can be used to measure total respiratory impedance in normal Standardbred horses (23). The purpose of this study was to investigate the effect of measurement frequency on total respiratory impedance in horses with naturally occurring reversible allergic airway disease. MATERIALS AND METHODSSix adult horses (three Standardbred, one Thoroughbred, one Arabian cross, and one Quarterhorse) affected by naturally occurring reversible allergic airway obstruction (heaves) and accustomed to being handled were used in the experiment. Their mean weight was 512 6 28 (SD) kg, and their mean age was 12.7 6 2.3 yr. The horses were housed and cared for in accordance with the recommendations of the Canadian Council on Animal Care, and the experimental protocol was approved by the Animal Care Committee of the University of Guelph. The horses were kept at pasture for sev...

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Section: Discussionmentioning

confidence: 99%

Frequency dependence of forced oscillatory respiratory mechanics in horses with heaves

Young

Tesarowski

Viel

1997

Journal of Applied Physiology

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“…The difference observed between our group 1 and 2 patients is not due to a particular observation tilting the mean in small groups. In particular, there is no The negative slope of resistance at low frequencies associated with a low reactance is not specific to pulmonary vascular congestion and has been described in obstructive lung diseases 14,24,29,30 Mechanical inhomogeneities of the lung and upper airways have usually been invoked to interpret this characteristic Zrs frequency dependence.11 14,30 According to the model described by Mead,3 an increase in slope of resistance vs frequency could be associated with an increase of resistance of the small airways. Numerous animal4'1 and human studies'8 have shown that pulmonary vascular congestion could induce small airways dysfunction, as shown by an increase in closing volume and peripheral airways resistance and by a decrease in dynamic compliance.…”

Section: Discussionmentioning

confidence: 99%

Respiratory system impedance in patients with acute left ventricular failure: pathophysiology and clinical interest.

Depeursinge¹,

Depeursinge²,

Boutaleb³

et al. 1986

Circulation

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386-395, 1986. ALTERATIONS in lung function have been shown to be related to hemodynamic impairment.' -Pulmonary vascular distension due to increased pulmonary blood volume appears as one of the early processes involved in the perturbations of lung mechanics.4 1 A specific increase in the small airways resistance, which may be due to "competition for space between the vessel and airway in the bronchovascular sheath," has been observed in the dog with an increase in left atrial pressure from 0 to 15 mm Hg.4 Similarly, a reversible decrease in lung compliance with increasing left atrial pressure in the phase of rapid rise of pulmonary blood volume has been described in the isolated rabbit lung.5 In man, the rapid increase in left end-diastolic pressure observed during anginal syndrome has been shown to be accompanied by a significant fall in lung compliance and in specific conductance.

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“…Respiratory resistance Respiratory resistance (Rrs) was measured using a forced oscillation technique (Fuller et al, 1988;Landser et al, 1976). Three measurements of respiratory resistance were made before and a further measurement was made after single breaths of capsaicin at doses which caused less than two coughs.…”

Section: Challengesmentioning

confidence: 99%

Modulation of capsaicin induced airway reflexes in humans: effect of monoamine oxidase inhibition.

Choudry

Studham

Harland

et al. 1993

Brit J Clinical Pharma

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A new method to determine frequency characteristics of the respiratory system

Cited by 236 publications

References 7 publications

Frequency dependence of forced oscillatory respiratory mechanics in horses with heaves

Frequency dependence of forced oscillatory respiratory mechanics in horses with heaves

Respiratory system impedance in patients with acute left ventricular failure: pathophysiology and clinical interest.

Modulation of capsaicin induced airway reflexes in humans: effect of monoamine oxidase inhibition.

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