A New Method toward Microengineered Surfaces Based on Reactive Coating

Lahann, Jörg; Choi, Insung S.; Lee, Jinwook; Jensen, Klavs F.; Langer, Robert

doi:10.1002/1521-3773(20010903)40:17<3166::aid-anie3166>3.0.co;2-#

Cited by 99 publications

(77 citation statements)

References 42 publications

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“…Recently, we established a surface modification technique based on the chemical vapor deposition (CVD) polymerization of substituted [2,2]paracyclophanes, to prepare a diverse class of functionalized poly(p-xylylene)s with a wide variety of functional groups such as amines, esters, and alcohols, which can be used for covalent binding of biomolecules. [9][10][11][12][13][14][15] Advantages of the CVD technique include control of the composition and architecture of the films, high accuracy, solvent-free environments, and excellent adhesion. This technique fulfills the need for a simple and broadly applicable surface modification system that creates stable platforms, which present a variety of reactive functional groups.…”

Section: Introductionmentioning

confidence: 99%

Vapor‐Based Synthesis of Poly[(4‐formyl‐p‐xylylene)‐co‐(p‐xylylene)] and Its Use for Biomimetic Surface Modifications

Nandivada¹,

Chen²,

Lahann³

2005

Macromol. Rapid Commun.

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Section: Introductionmentioning

confidence: 99%

Vapor‐Based Synthesis of Poly[(4‐formyl‐p‐xylylene)‐co‐(p‐xylylene)] and Its Use for Biomimetic Surface Modifications

Nandivada¹,

Chen²,

Lahann³

2005

Macromol. Rapid Commun.

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“…The colloids were then selectively activated via spatially directed illumination with the DMD, resulting in exclusive immobilization onto light-exposed surface areas only. To visualize the micropatterns, surface-modified colloids were further incubated with TRITC-labeled strepdavidin, which has been shown to bind to surface areas that present biotin ligands with high affinity (36). Fig.…”

Section: Resultsmentioning

confidence: 99%

Colloids with high-definition surface structures

Chen¹,

Rouillard²,

Gülari³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Compared with the well equipped arsenal of surface modification methods for flat surfaces, techniques that are applicable to curved, colloidal surfaces are still in their infancy. This technological gap exists because spin-coating techniques used in traditional photolithographic processes are not applicable to the curved surfaces of spherical objects. By replacing spin-coated photoresist with a vapor-deposited, photodefinable polymer coating, we have now fabricated microstructured colloids with a wide range of surface patterns, including asymmetric and chiral surface structures, that so far were typically reserved for flat substrates. This highthroughput method can yield surface-structured colloidal particles at a rate of Ϸ10 7 to 10 8 particles per operator per day. Equipped with spatially defined binding pockets, microstructured colloids can engage in programmable interactions, which can lead to directed self-assembly. The ability to create a wide range of colloids with both simple and complex surface patterns may contribute to the genesis of previously unknown colloidal structures and may have important technological implications in a range of different applications, including photonic and phononic materials or chemical sensors.biomaterials ͉ chemical vapor deposition polymerization ͉ polymer coatings ͉ surface engineering ͉ self-assembly C omplex colloidal structures have been a major focus of fundamental and applied research because of their potential applications in photonic (1-6) or phononic (7) band gap materials, chemical sensors (8), or data storage devices (9). Many of these applications will require colloids to be organized in nontrivial colloidal crystal structures with exquisite lattice periodicity, such as the diamond lattice (10). In principle, cocrystallization of binary mixtures of oppositely charged particles can form a range of unusual colloidal crystals (11)(12)(13)(14)(15)(16)). An alternate approach relies on the use of colloids that have spatially defined binding patches to encode and ultimately direct lattice organization (10). Although the potential merits of such an approach, e.g., homogenous colloidal assemblies and potentially superior optical properties, have been widely recognized (10, 17), successful experimental implementation has been hampered by the limited availability of suitable surface modification protocols for colloidal particles (18)(19)(20)(21). This limited availability of microstructuring techniques stands in clear contrast to the sizable number of patterning processes that have been developed for flat surfaces (22, 23), contributing to major technological breakthroughs in electronics and biotechnology (24).Recently, chemical vapor deposition (CVD) polymerization, a solventless coating process, which relies on the deposition of reactive coatings made of functionalized poly-p-xylylenes, has been developed as a flexible surface modification approach (25). Reactive coatings have been used to prepare polymer films with a wide range of functional groups, such as photoreact...

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“…The streptavidincoated surface was prepared according to a procedure published elsewhere. [20] Briefly, a silicon substrate was coated with poly[para-xylylene carboxylic acid pentafluorophenolester-co-para-xylylene] and the active ester groups of the polymer were used to bind (+)-biotinyl-3,6,9-trioxaundecanediamine onto the surface. Subsequent incubation with streptavidin resulted in a streptavidin-coated surface.…”

Section: Anti-thrombin Activity Of Hirudin-streptavidin Conjugatesmentioning

confidence: 99%

Universal Approach Towards r-Hirudin Derivatives with High Anti-Thrombin Activity Based on Chemical Differentiation of Primary Amino Groups

et al. 2002

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A New Method toward Microengineered Surfaces Based on Reactive Coating

Cited by 99 publications

References 42 publications

Vapor‐Based Synthesis of Poly[(4‐formyl‐p‐xylylene)‐co‐(p‐xylylene)] and Its Use for Biomimetic Surface Modifications

Vapor‐Based Synthesis of Poly[(4‐formyl‐p‐xylylene)‐co‐(p‐xylylene)] and Its Use for Biomimetic Surface Modifications

Colloids with high-definition surface structures

Universal Approach Towards r-Hirudin Derivatives with High Anti-Thrombin Activity Based on Chemical Differentiation of Primary Amino Groups

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