A New Methoxyiminoacetamide Fungicide, SSF-126, May Concomitantly Exert Fungicidal Activity with Constituents in Healthy Rice Leaves.

Kume, Ryuichi; Niikawa, Motomu; Kawaguchi, Akira; Yasumi, Keiichirou; Masuko, Michio; Shiraishi, Takeshi

doi:10.3186/jjphytopath.63.110

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Under field conditions, the application of AZ is effective unless AZ-resistant mutants appear (Tamura et al, 1999). This has been attributed to the fact that flavonoid compounds of the host plant suppress the AOX pathway, the 'flavonoid hypothesis' (Kume et al, 1997;Wood & Hollomon, 2003). In Magnaporthe oryzae, metominostrobin was effective in planta but ineffective on agar medium (Mizutani et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Cytological evaluation of the effect of azoxystrobin and alternative oxidase inhibitors in Botrytis cinerea

Inoue

Tsurumi

Ishii

et al. 2011

FEMS Microbiol Lett

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Azoxystrobin (AZ), a strobilurin-derived fungicide, is known to inhibit mitochondrial respiration in fungi by blocking the electron transport chain in the inner mitochondrial membrane. Germination was strongly inhibited when Botrytis cinerea spore suspension was treated with AZ and the alternative oxidase (AOX) inhibitors, salicylhydroxamic acid (SHAM) and n-propyl gallate. However, chemical death indicators trypan blue and propidium iodide showed that those spores were still alive. When the spore suspension in the AZ and SHAM solution was replaced with distilled water, the germination rate almost recovered, at least during the first 2 days of incubation with AZ and SHAM solution. No morphological alteration was detected in the cells treated with AZ and SHAM, especially in mitochondria, using transmission electron microscopy. Therefore, simultaneous application of AZ and AOX inhibitors has a fungistatic, rather than a fungicidal, action.

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Section: Discussionmentioning

confidence: 99%

Cytological evaluation of the effect of azoxystrobin and alternative oxidase inhibitors in Botrytis cinerea

Inoue

Tsurumi

Ishii

et al. 2011

FEMS Microbiol Lett

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“…In M grisea , AOX induction by metominostrobin was prevented by addition of flavone (see Section 4.2). In further experiments, spore germination in the presence of metominostrobin was greatly reduced by addition of the supernatant from a rice leaf homogenate 50. For example, with metominostrobin at 1000 µg litre −1 , the supernatant reduced germination from 90 to 20%.…”

Section: What Determines Aox Activity?mentioning

confidence: 92%

A critical evaluation of the role of alternative oxidase in the performance of strobilurin and related fungicides acting at the Q_o site of Complex III

Wood

Hollomon

2003

Pest Management Science

179

116

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Mitochondrial respiration conserves energy by linking NADH oxidation and electron-coupled proton translocation with ATP synthesis, through a core pathway involving three large protein complexes. Strobilurin fungicides block electron flow through one of these complexes (III), and disrupt energy supply. Despite an essential need for ATP throughout fungal disease development, strobilurins are largely preventative; indeed some diseases are not controlled at all, and several pathogens have quickly developed resistance. Target-site variation is not the only cause of these performance difficulties. Alternative oxidase (AOX) is a strobilurin-insensitive terminal oxidase that allows electrons from ubiquinol to bypass Complex III. Its synthesis is constitutive in some fungi but in many others is induced by inhibition of the main pathway. AOX provides a strobilurin-insensitive pathway for oxidation of NADH. Protons are pumped as electrons flow through Complex I, but energy conservation is less efficient than for the full respiratory chain. Salicylhydroxamic acid (SHAM) is a characteristic inhibitor of AOX, and several studies have explored the potentiation of strobilurin activity by SHAM. We present a kinetic-based model which relates changes in the extent of potentiation during different phases of disease development to a changing importance of energy efficiency. The model provides a framework for understanding the varying efficacy of strobilurin fungicides. In many cases, AOX can limit strobilurin effectiveness once an infection is established, but is unable to interfere significantly with strobilurin action during germination. A less stringent demand for energy efficiency during early disease development could lead to insensitivity towards this class of fungicides. This is discussed in relation to Botrytis cinerea, which is often poorly controlled by strobilurins. Mutations with a similar effect may explain evidence implicating AOX in resistance development in normally well-controlled plant pathogens, such as Venturia inaequalis.

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Uses and challenges of novel compounds for plant disease control

Leroux²,

2000

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A New Methoxyiminoacetamide Fungicide, SSF-126, May Concomitantly Exert Fungicidal Activity with Constituents in Healthy Rice Leaves.

Cited by 5 publications

References 8 publications

Cytological evaluation of the effect of azoxystrobin and alternative oxidase inhibitors in Botrytis cinerea

Cytological evaluation of the effect of azoxystrobin and alternative oxidase inhibitors in Botrytis cinerea

A critical evaluation of the role of alternative oxidase in the performance of strobilurin and related fungicides acting at the Q_o site of Complex III

Uses and challenges of novel compounds for plant disease control

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A New Methoxyiminoacetamide Fungicide, SSF-126, May Concomitantly Exert Fungicidal Activity with Constituents in Healthy Rice Leaves.

Cited by 5 publications

References 8 publications

Cytological evaluation of the effect of azoxystrobin and alternative oxidase inhibitors in Botrytis cinerea

Cytological evaluation of the effect of azoxystrobin and alternative oxidase inhibitors in Botrytis cinerea

A critical evaluation of the role of alternative oxidase in the performance of strobilurin and related fungicides acting at the Qo site of Complex III

Uses and challenges of novel compounds for plant disease control

Contact Info

Product

Resources

About

A critical evaluation of the role of alternative oxidase in the performance of strobilurin and related fungicides acting at the Q_o site of Complex III