A new mixed model of periodontitis‐induced preeclampsia: A pilot study

Mata, Karina M.; Nobre, Átila Vinícius Vítor; Silva, Pedro Henrique Félix; Oliezer, Renê Seabra; Fernandes, Cleverson Rodrigues; Amaral, Jefferson H.; Ramos, J. Galvão; Del-Arco, Marina Constante Gabriel; Messora, Michel Reis; Tanus‐Santos, José Eduardo; Gerlach, Raquel Fernanda; Salvador, Sérgio Luiz de Souza

doi:10.1111/jre.12869

Cited by 6 publications

(4 citation statements)

References 58 publications

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“…SH9H-2020-A358-1) and conformed to the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. A sample of 8 animals per group was used (Mata et al 2021).…”

Section: Methodsmentioning

confidence: 99%

Intestinal Translocation of Live Porphyromonas gingivalis Drives Insulin Resistance

Niu,

Lv,

Zhu

et al. 2024

J Dent Res

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Periodontitis has been emphasized as a risk factor of insulin resistance–related systemic diseases. Accumulating evidence has suggested a possible “oral–gut axis” linking oral infection and extraoral diseases, but it remains unclear whether periodontal pathogens can survive the barriers of the digestive tract and how they play their pathogenic roles. The present study established a periodontitis mouse model through oral ligature plus Porphyromonas gingivalis inoculation and demonstrated that periodontitis aggravated diet-induced obesity and insulin resistance, while also causing P. gingivalis enrichment in the intestine. Metabolic labeling strategy validated that P. gingivalis could translocate to the gastrointestinal tract in a viable state. Oral administration of living P. gingivalis elicited insulin resistance, while administration of pasteurized P. gingivalis had no such effect. Combination analysis of metagenome sequencing and nontargeted metabolomics suggested that the tryptophan metabolism pathway, specifically indole and its derivatives, was involved in the pathogenesis of insulin resistance caused by oral administration of living P. gingivalis. Moreover, liquid chromatography–high-resolution mass spectrometry analysis confirmed that the aryl hydrocarbon receptor (AhR) ligands, mainly indole acetic acid, tryptamine, and indole-3-aldehyde, were reduced in diet-induced obese mice with periodontitis, leading to inactivation of AhR signaling. Supplementation with Ficz (6-formylindolo (3,2-b) carbazole), an AhR agonist, alleviated periodontitis-associated insulin resistance, in which the restoration of gut barrier function might play an important role. Collectively, these findings reveal that the oral–gut translocation of viable P. gingivalis works as a fuel linking periodontitis and insulin resistance, in which reduction of AhR ligands and inactivation of AhR signaling are involved. This study provides novel insight into the role of the oral–gut axis in the pathogenesis of periodontitis-associated comorbidities.

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“…SH9H-2020-A358-1) and conformed to the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. A sample of 8 animals per group was used (Mata et al 2021).…”

Section: Methodsmentioning

confidence: 99%

Intestinal Translocation of Live Porphyromonas gingivalis Drives Insulin Resistance

Niu,

Lv,

Zhu

et al. 2024

J Dent Res

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“…During the second trimester, pregnant women are at higher risk of hypertension, clinically evident in 8% of pregnant patients ( Barr et al, 2022 ), characterized by poorer oral health and a higher incidence of complications with local anesthesia ( Mata et al, 2021 ). During dental treatment, fear and pain are the most common causes of high blood pressure.…”

Section: Survey Methodologymentioning

confidence: 99%

Physiology of pregnancy and oral local anesthesia considerations

Zhou

Zhong

Pan

et al. 2023

PeerJ

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Background Safe and effective local anesthesia is a prerequisite for emergency oral surgeries and most dental treatments. Pregnancy is characterized by complex physiological changes, and increased sensitivity to pain. Pregnant women are particularly vulnerable to oral diseases, such as caries, gingivitis, pyogenic granuloma and third molar pericoronitis. Maternally administered drugs can affect the fetus through the placenta. Therefore, many physicians and patients are reluctant to provide or accept necessary local anesthesia, which leads to delays in the condition and adverse consequences. This review is intended to comprehensively discuss the instructions for local anesthesia in the oral treatment of pregnant patients. Methodology An in-depth search on Medline, Embase, and the Cochrane Library was performed to review articles concerned with maternal and fetal physiology, local anesthetic pharmacology, and their applications for oral treatment. Results Standard oral local anesthesia is safe throughout the pregnancy. At present, 2% lidocaine with 1:200,000 epinephrine is considered to be the anesthetic agent that best balances safety and efficacy for pregnant women. Maternal and fetal considerations must be taken into account to accommodate the physiological and pharmacological changes in the gestation period. Semi-supine position, blood pressure monitoring, and reassurance are suggested for high-risk mothers to reduce the risk of transient changes in blood pressure, hypoxemia, and hypoglycemia. For patients with underlying diseases, such as eclampsia, hypertension, hypotension, and gestational diabetes, the physicians should use epinephrine cautiously and control the dose of anesthetic. New local anesthesia formulations and equipment, which contribute to minimizing injection pain and relieving the anxiety, have and are being developed but remain understudied. Conclusions Understanding the physiological and pharmacological changes during pregnancy is essential to ensure the safety and efficiency of local anesthesia. Optimal outcomes for the mother and fetus hinge on a robust understanding of the physiologic alterations and the appropriate selection of anesthetic drugs and approaches.

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“…A cross-sectional study recording clinical periodontal parameters and assessing serum C-reactive protein levels confirmed that poor maternal periodontal status, increased oral inflammatory burden and increased systemic inflammation had an adverse effect on infant birth weight ( 18 ). In addition, it was suggested that periodontal infection could exacerbate the progression of pre-eclampsia, and periodontal disease was considered to be one of the risk factors for pre-eclampsia ( 19 , 20 ).…”

Section: The Association Between Periodontal Disease and Adverse Preg...mentioning

confidence: 99%

Periodontal disease in pregnancy and adverse pregnancy outcomes: Progress in related mechanisms and management strategies

2022

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Periodontal disease is an inflammatory and destructive disease of tissues supporting the tooth. A large number of studies have confirmed that periodontal pathogens and their metabolites can lead to adverse pregnancy outcomes in direct or indirect ways. Adverse pregnancy outcomes, such as preterm birth, low birth weight, and pre-eclampsia, have a serious impact on human reproductive health. In recent years, although the level of global medical technology has gradually improved, the incidence of adverse pregnancy outcomes has not declined and is still a global public health problem. The purpose of this review is to summarize the current data on periodontal disease in pregnancy and adverse pregnancy outcomes, including the association between periodontal disease and adverse pregnancy outcomes, the pathogenic mechanism related to this association, the efficacy of different nutrition supplements for both periodontal disease and adverse pregnancy outcomes and the effect of providing periodontal treatment on the occurrence of adverse pregnancy outcomes, to provide guidance for the prevention and treatment of adverse pregnancy outcomes in clinical practice.

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A new mixed model of periodontitis‐induced preeclampsia: A pilot study

Cited by 6 publications

References 58 publications

Intestinal Translocation of Live Porphyromonas gingivalis Drives Insulin Resistance

Intestinal Translocation of Live Porphyromonas gingivalis Drives Insulin Resistance

Physiology of pregnancy and oral local anesthesia considerations

Periodontal disease in pregnancy and adverse pregnancy outcomes: Progress in related mechanisms and management strategies

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