Nanomaterials having excellent thermal properties are employed in producing energy, extrusion processes, engineering processes, nuclear interactions, industrial domains and aero‐spaces, etc. Therefore, current study scrutinizes the aspects of entropy optimization and Ohmic heating on MHD peristalsis of fourth‐grade nanoliquid in a channel. Flexible channel walls retain concentration, thermal slip and velocity conditions. The consequences of viscous dissipation and Arrhenius activation have been accounted. The lubrication approximation is used in mathematical modelling. Nanofluid model is used by considering thermophoresis and Brownian motion. Furthermore, thermal radiation features are included in the energy equation. By using an appropriate similarity transformation, a system of PDEs is simplified to a solvable system of ODEs. Numerical techniques are used to solve the problem of governance. Detailed exploration of the sundry variables of concern on the flow quantities like velocity profile, nanoparticle concentration, temperature and entropy of the system is graphically examined. Heat transfer is examined in tabular form. Based on the derived outcomes, the velocity rises via thermal Grashof and slip variables. Further, an increment in Brownian motion and radiation parameters shows opposite behaviour on temperature.