A New Model Function for Continuous Data Sets in Health Risk Assessment of Chemicals Using the Benchmark Dose Concept

Kalliomaa, Kristiina; Haag‐Grönlund, Marie; Victorin, Katarina

doi:10.1006/rtph.1997.1184

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…Several standalone programs have also been developed over the last decades, such as the programs developed by Kalliomaa et al [16], but they seem to have vanished again. Another freely available program is the U.S. EPA's Benchmark Dose Software, specifically designed toward benchmark dose estimation.…”

Section: Software Considerationsmentioning

confidence: 98%

“…Examples are threshold models such as the hockey stick model [3,15,16] and the hormesis model introduced by Hunt and Bowman [17], but these models are not in common use, which may be due to the lack of a biological rationale for the existence of a threshold. Second-order and higher-order polynomial models, which have occasionally been used for modeling dose-response data [4,18,19] and polynomials in dose within the generalized linear model framework [20,21], are also not part of the general framework proposed in the present study, but these models are only occasionally useful in a dose-response context, as even interpolation can be unreliable [6].…”

Section: Dose-response Modelsmentioning

confidence: 99%

See 1 more Smart Citation

Toward a unified approach to dose–response modeling in ecotoxicology

Ritz

2010

Environmental Toxicology and Chemistry

274

221

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This study reviews dose-response models that are used in ecotoxicology. The focus lies on clarification of differences and similarities between models, and as a side effect, their different guises in ecotoxicology are unravelled. A look at frequently used dose-response models reveals major discrepancies, among other things in naming conventions. Therefore, there is a need for a unified view on dose-response modeling in order to improve the understanding of it and to facilitate communication and comparison of findings across studies, thus realizing its full potential. This study attempts to establish a general framework that encompasses most dose-response models that are of interest to ecotoxicologists in practice. The framework includes commonly used models such as the log-logistic and Weibull models, but also features entire suites of models as found in various guidance documents. An outline on how the proposed framework can be implemented in statistical software systems is also provided.

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Section: Software Considerationsmentioning

confidence: 98%

Section: Dose-response Modelsmentioning

confidence: 99%

Toward a unified approach to dose–response modeling in ecotoxicology

Ritz

2010

Environmental Toxicology and Chemistry

274

221

View full text Add to dashboard Cite

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“…The benchmark approach was extended (WHO/ IPCS, 2009a) to be used with dose-effect data (continuous data) and those obtained in epidemiological studies, where confounder adjustment is needed (Budtz-Jørgensen et al, 2001;Crump, 1995Crump, , 2002Kalliomaa et al, 1998). Such BMD calculations may be useful in risk assessments, but their implications in terms of health risk have usually not been defined or discussed.…”

Section: Benchmark Dose and Its Lower Confidence Limitmentioning

confidence: 99%

Risk Assessment

Nordberg¹,

Fowler²

2015

Handbook on the Toxicology of Metals

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“…In addition, an exponential model is also given in Table 2. This latter model class has been discussed and applied by Slob (2002), and a similar exponential model has been presented by Kalliomaa et al (1998).…”

Section: Dose-response Modelsmentioning

confidence: 97%

The current state of knowledge on the use of the benchmark dose concept in risk assessment

Sand

Victorin

Filipsson

2007

J of Applied Toxicology

Self Cite

102

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This review deals with the current state of knowledge on the use of the benchmark dose (BMD) concept in health risk assessment of chemicals. The BMD method is an alternative to the traditional no-observed-adverse-effect level (NOAEL) and has been presented as a methodological improvement in the field of risk assessment. The BMD method has mostly been employed in the USA but is presently given higher attention also in Europe. The review presents a number of arguments in favor of the BMD, relative to the NOAEL. In addition, it gives a detailed overview of the several procedures that have been suggested and applied for BMD analysis, for quantal as well as continuous data. For quantal data the BMD is generally defined as corresponding to an additional or extra risk of 5% or 10%. For continuous endpoints it is suggested that the BMD is defined as corresponding to a percentage change in response relative to background or relative to the dynamic range of response. Under such definitions, a 5% or 10% change can be considered as default. Besides how to define the BMD and its lower bound, the BMDL, the question of how to select the dose-response model to be used in the BMD and BMDL determination is highlighted. Issues of study design and comparison of dose-response curves and BMDs are also covered.

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A New Model Function for Continuous Data Sets in Health Risk Assessment of Chemicals Using the Benchmark Dose Concept

Cited by 13 publications

References 12 publications

Toward a unified approach to dose–response modeling in ecotoxicology

Toward a unified approach to dose–response modeling in ecotoxicology

Risk Assessment

The current state of knowledge on the use of the benchmark dose concept in risk assessment

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