A New Model of Laryngitis: Neuropeptide, Cyclooxygenase, and Cytokine Profile

Abstract

This NGI model results in laryngeal chronic inflammation without direct mechanical aggression of the mucosa and may contribute to the study of future therapeutic approaches to this pathology.

The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment

“…We previously demonstrated that NGI is a good model to study laryngitis in the rat since no direct lesion of the laryngeal epithelium is induced [9]. Additionally, we observed an overexpression of COX-2 enzyme in the laryngeal mucosa [9], which represents the inducible form of the COX enzyme following pathological stimulation in opposition to the constitutive COX-1 isoform [3].…”

“…Some studies showed a neurogenic component in some pathologies like asthma, rhinitis and rheumatoid arthritis [8]. Recently, we demonstrated a neurogenic factor in a new model of experimental laryngitis [9]. The intraepithelial nerve fibres of the larynx are important for bronchopulmonar defence [10].…”

“…These fibres project into the laryngeal lumen and are rich in SP and CGRP [10]. The release of these neuropeptides can induce neurogenic laryngitis as shown by the increased expression of inflammatory cytokines like interleukin-1b (IL-1b), IL-6 and tumour necrosis factor-a (TNF-a), and the decreased expression of the anti-inflammatory cytokine IL-10 [9].…”

“…Nasogastric intubation (NGI) is largely used in clinical practice and can induce important respiratory disorders like aspiration pneumonia or laryngitis [9,11,12]. We previously demonstrated that NGI is a good model to study laryngitis in the rat since no direct lesion of the laryngeal epithelium is induced [9].…”

Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features

“…COX-1 is constitutively expressed. COX-2 gene expression has been demonstrated to increase in response to cytokines, mitogens, and growth factors [7]. High expression of COX-2 in a wide variety of solid epithelial tumors also favors the growth of malignant cells by inhibition of apoptosis and the promotion of angiogenesis [8].…”