Three-dimensional (3D) printing is cited as "a novel, fascinating, future builder technology" in many papers and articles. Use of this technology in the field of medicine and especially oral and maxillofacial surgery is expanding. The type of manufacturing systems, materials, cost-effectiveness, and also bio-printing, with studies from around the world today, make this field a "hot-topic" in reconstructive and regenerative surgery. This chapter evaluates the latest updates and scientific uses of 3D printing.