A new monoterpenoid indole alkaloid from &lt;I&gt;Ervatamia chinensis&lt;/I&gt;

Guo, Ling‐Li; He, Hongping; Li, Yan; Yu, Jian; Hao, Xiao‐Jiang

doi:10.3724/sp.j.1009.2012.00226

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…For instance, vernavosine ethyl ester isolated from stem bark of the Malayan T. corymbosa induced moderate dose dependent relaxation effects on phenylephrine‐induced contraction in rat aortic rings with an EC 50 value of 2.48 μ m . Similarly, rutaecarpine recently isolated from whole plant of the Chinese T. corymbosa has been previously shown to induce vasorelaxation in phasic and tonic phases of phenylephrine‐induced contraction (1 μ m –0.1 m m ) via an endothelium dependent mechanism that involves nitric oxide and gaunylyl cyclase …”

Section: Pharmacological Activitymentioning

confidence: 99%

A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa

Abubakar

Loh

2016

Journal of Pharmacy and Pharmacology

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Objectives Tabernaemontana is a genus from the plant family, Apocynaceae with vast medicinal application and widespread distribution in the tropics and subtropics of Africa, Americas and Asia. The objective of this study is to critically evaluate the ethnobotany, medicinal uses, pharmacology and phytochemistry of the species, Tabernaemontana corymbosa (Roxb. ex Wall.) and provide information on the potential future application of alkaloids isolated from different parts of the plant. Key findings T. corymbosa (Roxb. ex Wall.) parts are used as poultice, boiled juice, decoctions and infusions for treatment against ulceration, fracture, postnatal recovery, syphilis, fever, tumours and orchitis in Malaysia, China, Thailand and Bangladesh. Studies recorded alkaloids as the predominant phytochemicals in addition to phenols, saponins and sterols with vast bioactivities such as antimicrobial, analgesic, anthelmintic, vasorelaxation, antiviral and cytotoxicity. Summary An evaluation of scientific data and traditional medicine revealed the medicinal uses of different parts of T. corymbosa (Roxb. ex Wall.) across Asia. Future studies exploring the structure-bioactivity relationship of alkaloids such as jerantinine and vincamajicine among others could potentially improve the future application towards reversing anticancer drug resistance.

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Section: Pharmacological Activitymentioning

confidence: 99%

A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa

Abubakar

Loh

2016

Journal of Pharmacy and Pharmacology

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“…Ervachinine E ( 316 ) [ 165 ] and rutaecarpine ( 317 ) [ 166 ] were isolated from E. chinensis [ 165 ]. It displayed moderate antitumor activities against HL-60, SMMC-7721, A-549, and SW480 cancer cells, with values of IC 50 ranging between 6.59 and 14.70 μM.…”

Section: Ervatamiamentioning

confidence: 99%

“…It displayed moderate antitumor activities against HL-60, SMMC-7721, A-549, and SW480 cancer cells, with values of IC 50 ranging between 6.59 and 14.70 μM. (Cisplatin, IC 50 values between 1.00 and 26.75 μM) [ 165 ].…”

Section: Ervatamiamentioning

confidence: 99%

“…This indicated that the electron-donor substituents attached at the phenyl group were important for the improvement of AChE inhibition [164]. Ervachinine E (316) [165] and rutaecarpine (317) [166] were isolated from E. chinensis [165]. It displayed moderate antitumor activities against HL-60, SMMC-7721, A-549, and SW480 cancer cells, with values of IC 50 ranging between 6.59 and 14.70 µM.…”

Section: Ervatamiamentioning

confidence: 99%

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Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera

et al. 2021

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By the end of the twentieth century, the interest in natural compounds as probable sources of drugs has declined and was replaced by other strategies such as molecular target-based drug discovery. However, in the recent times, natural compounds regained their position as extremely important source drug leads. Indole-containing compounds are under clinical use which includes vinblastine and vincristine (anticancer), atevirdine (anti-HIV), yohimbine (erectile dysfunction), reserpine (antihypertension), ajmalicine (vascular disorders), ajmaline (anti-arrhythmic), vincamine (vasodilator), etc. Monoterpene Indole Alkaloids (MIAs) deserve the curiosity and attention of researchers due to their chemical diversity and biological activities. These compounds were considered as an impending source of drug-lead. In this review 444 compounds, were identified from six genera belonging to the family Apocynaceae, will be discussed. These genera (Alstonia, Rauvolfia, Kopsia, Ervatamia, and Tabernaemontana, and Rhazya) consist of 400 members and represent 20% of Apocynaceae species. Only 30 (7.5%) species were investigated, whereas the rest are promising to be investigated. Eleven bioactivities, including antibacterial, antifungal, anti-inflammatory and immunosuppressant activities, were reported. Whereas cytotoxic effect represents 47% of the reported activities. Convincingly, the genera selected in this review are a wealthy source for future anticancer drug lead.

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“…Six vobasinyl-ibogan type bisindole alkaloids containing four new ones ervachinines A-D and ten known monoterpeniod indole alkaloids are descripted from the whole plant of Ervatamia chinensis (GUO & al [72]). Monoterpenoid indole and bisindole alkaloids with antitumor potential are previously reported from genus Ervatamia (HIRASAWA & al [73]).…”

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confidence: 99%

Anticancer Activity of Natural Bioactive Compounds against Human Carcinoma Cell Lines - A mini review

REHMAN¹,

Ashraf²,

Nazli³

et al. 2019

Rom Biotechnol Lett.

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Cancer is one of the most stern health dilemmas engulfing 7 million lives every year globally. It is group of more than 100 diseases. Conventional cancer therapies burdened the disease crippled patient with lethal side effects and are also very expensive. Therefore, the demand to use alternative approaches in treatment of cancer is escalating. Plants of earth are massive reservoir of bioactive compounds. Plant derived compounds such as protoapigenone, casticin, moursin, gypenosides VN5, kalopanaxsaponin A, sapindoside B7, maclekarpine C are foremost anticancer agents, due to their unique structure and sophisticated mechanism of action. The present review is aimed at compiling data on promising classes of bioactive compounds from medicinal plants and their anti cancer mechanism of action against different human carcinoma cell lines.

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A new monoterpenoid indole alkaloid from <I>Ervatamia chinensis</I>

Cited by 10 publications

References 11 publications

A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa

A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa

Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera

Anticancer Activity of Natural Bioactive Compounds against Human Carcinoma Cell Lines - A mini review

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