A new multifunctional hydroxytyrosol-clofibrate with hypolipidemic, antioxidant, and hepatoprotective effects

Xie, Yundong; Chen, Zizhang; Shao, Li‐Hua; Wang, Qiutang; Li, Na; Lu, Wen-Fang; Yan, Xu; Gao, Yali; Guo, Liying; Liu, Hao-Le; Li, Yiping; Yang, Guangde; Bian, Xiaoli

doi:10.1016/j.bmcl.2018.06.010

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…This dose did not influence blood lipids, but endogenous vitamin C levels were increased [36]. Moreover, HTyr-nicotinate, HTyr-clofibrate and HTyr-fenofibrate showed the antihyperlipidemic effect [37,38,39]. HTyr and HTyr-acetate (HTyr-Ac) were proved to prevent platelet aggregation, one of the factors involved in thrombotic processes, with effects similar to acetylsalicylic acid [40].…”

Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

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Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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“…In another study, Xie et al (2018) investigated the effects of hydroxytyrosol-clofibrate (CF-HT, 240 µmol/kg/day for 7 days) in hyperlipidemic mice (induced with Triton WR-1339) showing decreased plasma total cholesterol and triglyceride levels, a protective effect on hepatic tissue (decreased AST, ALT, total bilirubin (TBIL), alkaline phosphatase (ALP)), and increased serum SOD and CAT. The CF-HT treatment additionally decreased serum MDA and hepatic oxidized glutathione (GSSH) while increasing hepatic glutathione (GSH) (Table 8) [74].…”

Section: In Vivo Evidence: Antidiabetic Effect Of Hydroxytyrosolmentioning

confidence: 99%

“…The harmful impact of hyperglycemia and lack of insulin production on the liver, heart, brain, pancreas, and retinal cells of the eye were also alleviated by HT [47,55,56,58,59,60,61,62,72,73,74]. Secondary experiments using Triton WR-1339 to chemically induce hyperlipidemia also showed that HT decreased serum lipids and liver damage [72,74]. HT has also been studied in genetic db/db C57BL/6J mouse models of diabetes, which lack leptin receptors and develop obesity and hyperglycemia [75].…”

Section: In Vivo Evidence: Antidiabetic Effect Of Hydroxytyrosolmentioning

confidence: 99%

“…HT reduced oxidative stress in muscle [30,63], liver [42,44,46,47,55,63,68,74], pancreas [56], kidney [65], heart [65], and brain tissue [60,64], as shown by the decreased levels of markers of oxidative stress such as NO and MDA and the increased activity of antioxidant enzymes including SOD, CAT, GSH and GPX. Additionally, HT reduced the inflammatory effects of TNF-α, and inhibited downstream the activation of JNK in adipocytes [37].…”

Section: Effects Of Hydroxytyrosol (Ht) On Cellular Signaling Cascmentioning

confidence: 99%

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Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence

2019

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Insulin resistance, a pathological condition characterized by defects in insulin action leads to the development of Type 2 diabetes mellitus (T2DM), a disease which is currently on the rise that pose an enormous economic burden to healthcare systems worldwide. The current treatment and prevention strategies are considerably lacking in number and efficacy and therefore new targeted therapies and preventative strategies are urgently needed. Plant-derived chemicals such as metformin, derived from the French lilac, have been used to treat/manage insulin resistance and T2DM. Other plant-derived chemicals which are not yet discovered, may have superior properties to prevent and manage T2DM and thus research into this area is highly justifiable. Hydroxytyrosol is a phenolic phytochemical found in olive leaves and olive oil reported to have antioxidant, anti-inflammatory, anticancer and antidiabetic properties. The present review summarizes the current in vitro and in vivo studies examining the antidiabetic properties of hydroxytyrosol and investigating the mechanisms of its action.

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“…In previous studies, triton‐1339W is reported to cause hyperlipidemia through inhibiting lipoprotein lipase and over‐activating the enzyme HMG‐CoA reductase (Zarzecki et al, ) and triton‐1339W‐induced acute liver injury (Xie et al, ). In our experiment, liver morphological change (irregulative center vein, inflammation inflirtation, and ballooning degeneration) and markers of liver injury (increase in GOT and GPT) are found after challenge of Trition‐1339W.…”

Section: Discussionmentioning

confidence: 97%

Tanshinol A Ameliorates Triton‐1339W‐Induced Hyperlipidemia and Liver Injury in C57BL/6J Mice by Regulating mRNA Expression of Lipemic‐Oxidative Injury Genes

Yuxing²,

Huang³

et al. 2020

Lipids

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Tanshinol A, which is derived from a traditional Chinese herbal Radix Salviae Miltiorrhizae is indicative of a hypolipidemic candidate. Therefore, we aim to validate its hypolipidemic activity of tanshinol A and explore its mechanism in triton‐1339W‐induced hyperlipidemic mice model, which possess multiply pathogenesis for endogenous lipid metabolism disorder. Experimental hyperlipidemia mice are treated with or without tanshinol A (i.g. 40, 20, 10 mg/kg), and blood and liver tissue were collected for validating its hypolipidemic and hepatic protective effect, and hepatic mRNA expression profile, which was associated with lipid metabolism dysfunction and liver injury, was detected by RT‐qPCR. As results show, triton‐1339W‐induced abnormal of serum TC, TAG, HDL‐C, LDL‐C, SOD, MDA, GOT, and GPT is remarkably attenuated by tanshinol A. In pathological experiment, triton‐1339W‐induced hepatocellular ballooning degeneration, irregular central vein congestion, and inflammation infiltration are alleviated by tanshinol A. Correspondingly, hepatic mRNA expression of Atf4, Fgf21, Vldlr, Nqo1, Pdk4, and Angptl4, which are genes regulating lipemic‐oxidative injury, are significantly increased by tanshinol A by 2~6 fold. Abcg5, Cd36, and Apob, which are responsible for cholesterol metabolism, are mildly upregulated. Noticeably, triton‐1339W‐suppressed expressions of Ptgs2/Il10, which are genes responsible for acute inflammation resolution in liver injury, are remarkably increased by tanshinol A. Conclusively, tanshinol A exerted hypolipidemic effect and hepatoprotective effect through restoring triton‐1339W‐suppressed mRNA expression, which may be involved in Atf4/Fgf21/Vldlr and Ptgs2/Il‐10 signaling pathways.

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A new multifunctional hydroxytyrosol-clofibrate with hypolipidemic, antioxidant, and hepatoprotective effects

Cited by 13 publications

References 20 publications

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence

Tanshinol A Ameliorates Triton‐1339W‐Induced Hyperlipidemia and Liver Injury in C57BL/6J Mice by Regulating mRNA Expression of Lipemic‐Oxidative Injury Genes

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