A new multiple myeloma cell line, MEF-1, possesses cyclin d1 overexpression and the p53 mutation

Yufu, Yuji; Goto, Takafumi; Choi, Ilseung; Uike, Naokuni; Kozuru, Mitsuo; Ohshima, Koichi; Taniguchi, Toshiyasu; Motokura, Toru; Yatabe, Yasushi; Nakamura, Shigeo

doi:10.1002/(sici)1097-0142(19990415)85:8<1750::aid-cncr15>3.0.co;2-5

Cited by 9 publications

(3 citation statements)

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“…Therefore, overexpression of cyclin D1 may only be one step in the multistep oncogenesis and other events (i.e. mutations of the p53 gene) may also be necessary for the establishment of the disease [36].…”

Section: Genetic Alterations Affecting Genes Involved In Cell-cycle Rmentioning

confidence: 99%

“…Inactivation of CDK inhibitors may be an important event in the development and/ or progression of MM [36]. Homozygous deletions of p15 and p16 may occur, as found in cases of plasma cell leukemia.…”

Section: Genetic Alteration Of Cdk (Cyclin-dependent Kinase) Inhibitomentioning

confidence: 99%

“…p53 mutations are relatively rare and have been detected in association with more advanced stages of the disease, suggesting that p53 mutation is a late event in MM [36,39].…”

Section: Genetic Alteration Of Cdk (Cyclin-dependent Kinase) Inhibitomentioning

confidence: 99%

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Functional significance of genetic abnormalities in multiple myeloma

Gadó¹,

Domján²,

Kormos

et al. 2002

Haematologia

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Multiple myeloma (MM) is a B-cell neoplasm characterized by infiltration of the bone marrow with malignant plasma cells, synthesizing and secreting monoclonal immunoglobulin fragments. The malignant transformation of this terminally differentiated plasma cell is the result of a multistep transformation process. In spite of recent advances in this field, the cause and the exact molecular genetic basis of MM remain obscure. In this review, an attempt has been made to summarize the genetic alterations having functional significance in the generation and progression of MM, and also the existing relationship between genetic abnormalities and chemosensitivity, as well as the typical genetic alterations in various MM subgroups. Factors known to have a role in the conversion of monoclonal gammopathy of unknown significance (MGUS) to MM are also reviewed.

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Section: Genetic Alterations Affecting Genes Involved In Cell-cycle Rmentioning

confidence: 99%

Section: Genetic Alteration Of Cdk (Cyclin-dependent Kinase) Inhibitomentioning

confidence: 99%