A New Non-Invasive Statistical Method to Assess the Spontaneous Cardiac Baroreflex in Humans

Ducher, Michel; Fauvel, Jean Pierre; Gustin, Marie Paule; Cerutti, Catherine; Najem, Robert; Cuisinaud, G.; Laville, Maurice; Pozet, N; Paultre, Christian

doi:10.1042/cs0880651

Cited by 30 publications

(32 citation statements)

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“…3 The determination of BRS in the temporal domain using the sequence method had consistently been reported to be strongly correlated with spectral BRS determination. [15][16][17][18] As in our experience the sequence method appeared to be slightly less reproducible at short term (1 week), we now only determine BRS in the frequency domain. Recently, Johnston et al also reported lower coefficients of variation and reproducibility coefficients if BRS were determined with the spectral method instead of the sequence method.…”

Section: Figure 1 Correlations Between Age and S-brs At Inclusion (Amentioning

confidence: 99%

“…Because S-BRS is partly derived from SBP determination, any estimate of its time evolution is limited by the time evolution of the BP signal. Because S-BRS is reproducible in the short term 15,[23][24][25] and has a predictable evolution in the long term, S-BRS can be considered an intrinsic characteristic of each subject and therefore used in research studies and clinical practice.…”

Section: Figure 1 Correlations Between Age and S-brs At Inclusion (Amentioning

confidence: 99%

“…15 In brief, BP signals were sampled at a rate of 100 Hz and data were stored for further processing. Data processing was performed on a 4-minute recording.…”

Section: Bp Signal Analysismentioning

confidence: 99%

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Aging Process on Spectrally Determined Spontaneous Baroreflex Sensitivity

et al. 2007

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Abstract-The interindividual age-related decrease in baroreflex sensitivity (BRS) was reported in many cross-sectional studies. However, the long-term intraindividual decrease in BRS has never been confirmed by longitudinal studies. Data obtained from a 5-year prospective study designed to assess the 5-year stress effects on blood pressure (BP) provided the opportunity to assess longitudinal aging process on spectrally determined BRS (S-BRS) using the cross spectral analysis. This analysis was carried out in 205 men aged between 18 and 50 years who had 2 valid beat to beat BP recordings (Finapress) at a mean 5-year interval. At inclusion and at end of follow-up, S-BRS was significantly correlated with age (rϭϪ0. 50, PϽ0.001, rϭϪ0.33, PϽ0.001 respectively). Interestingly, the slopes and the intercepts were not significantly different at a 5-year interval. This result is in favor of the good reproducibility of S-BRS. The attenuation with age of S-BRS was calculated at 3.6% a year. This decrease was slightly higher than the one obtained with the baseline data (2.3% per year). This longitudinal study provided, for the first time, an estimate of the slope of the age-related physiological S-BRS decrease in a mid-aged healthy male population. Our findings reinforce the interest of evaluating spontaneous BRS reported to predict hypertension and cardiovascular events in various populations. Key Words: mental stress Ⅲ baroreflex Ⅲ hypertension Ⅲ blood pressure Ⅲ reproducibility B aroreflex sensitivity (BRS) is a relevant index of the autonomic control of blood pressure (BP). Historically, BRS was determined using drug-induced BP and heart rate (HR) opposite variations. More recently, noninvasive techniques of determining spontaneous BRS have been implemented, 1-3 the spectral method being one of the most popular. The spectral determination of BRS (S-BRS) is a reliable measure of BRS because it has often been reported to be correlated with the pharmacologically determined BRS. 4 -7 S-BRS is easy to determine, and repeated measures are easy to make. Aging process on S-BRS has already been reported in several cross sectional studies. 8 -12 Such studies only report interindividual S-BRS variation with age. Thus, S-BRS has consistently been reported to decrease with age. Physiological aging in men was associated with a marked reduction in baroreflex buffering. A differential aging process on baroreflex buffering BP and cardiovagal baroreflex was reported. 10 The decrease in baroreflex buffering with aging was related to an increase in basal sympathetic nerve activity and to a reduction in systemic Alpha1-adrenergic vascular responsiveness whereas the decrease in cardiovagal baroreflex was related to a decrease in parasympathetic pathways. 10,13 However, to our knowledge, the intraindividual BRS alteration with age has never been reported. For that purpose, we analyzed the S-BRS 5-year aging process in a cohort of 205 healthy young men. This unique data set was extracted from a 5-year follow-up study designed to assess stress ...

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Section: Figure 1 Correlations Between Age and S-brs At Inclusion (Amentioning

confidence: 99%

Section: Figure 1 Correlations Between Age and S-brs At Inclusion (Amentioning

confidence: 99%

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Aging Process on Spectrally Determined Spontaneous Baroreflex Sensitivity

et al. 2007

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“…A Z-coefficient statistical method has also been proposed [12], but the method needs long recording periods to reliably estimate the required probability functions.…”

Section: A) Time-domain Methodsmentioning

confidence: 99%

A system identification approach to baroreflex sensitivity estimation

McLoone

Ringwood

2012

IET Irish Signals and Systems Conference (ISSC 2012)

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-The body contains a bewildering array of regulatory systems which maintain homeostasis. There is considerable difficulty in isolating a single control loop for analysis, due to the interactions with other systems/loops. One important such regulatory loop is the baroreflex, and baroreflex sensitivity is a characteristic open-loop parameter which can help us to assess the health of the baroreflex. A diverse range of methods have been proposed to determine baroreflex sensitivity from experimental data. Unfortunately, there appears to be little consistency of result among the different methods and some explanation can be found in the nature of the problem: In most cases, an attempt is being made to determine open-loop measures from a system operating in closed-loop, subject to poor excitation. In this paper we propose a strict procedure, based on a rigourous mathematical framework, from which reliable estimates of baroreflex sensitivity can be obtained. A comparison with other methods for baroreflex sensitivity estimation, using the EuroBaVar data set, is performed.

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“…α HF ). An alternative way to quantify BRS was introduced by Ducher et al [1995], where the relation between SBP values and BBI is assessed statistically. The statistical level of coupling is quantified by the Z-index, which is a function of SBP and BBI.…”

Section: Baroreceptor Sensitivitymentioning

confidence: 99%

Nonlinear Methods of Cardiovascular Physics and Their Clinical Applicability

Wessel

Malberg²,

Bauernschmitt

et al. 2007

Int. J. Bifurcation Chaos

102

107

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In this tutorial we present recently developed nonlinear methods of cardiovascular physics and show their potentials to clinically relevant problems in cardiology. The first part describes methods of cardiovascular physics, especially data analysis and modeling of noninvasively measured biosignals, with the aim to improve clinical diagnostics and to improve the understanding of cardiovascular regulation. Applications of nonlinear data analysis and modeling tools are various and outlined in the second part of this tutorial: monitoring-, diagnosis-, course and mortality prognoses as well as early detection of heart diseases. We show, that these data analyses and modeling methods lead to significant improvements in different medical fields.Keywords: Cardiovascular physics; nonlinear data analysis and modeling; heart rate and blood pressure variability; baroreflex sensitivity. List of Abbreviations

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A New Non-Invasive Statistical Method to Assess the Spontaneous Cardiac Baroreflex in Humans

Cited by 30 publications

References 0 publications

Aging Process on Spectrally Determined Spontaneous Baroreflex Sensitivity

Aging Process on Spectrally Determined Spontaneous Baroreflex Sensitivity

A system identification approach to baroreflex sensitivity estimation

Nonlinear Methods of Cardiovascular Physics and Their Clinical Applicability

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