A New, Noninvasive Method of Measuring Impaired Pulmonary Gas Exchange in Lung Disease: An Outpatient Study

West, John B.; Crouch, Daniel R.; Fine, Janelle M.; Makadia, Dipen; Wang, Daniel L.; Prisk, G. Kim

doi:10.1016/j.chest.2018.02.001

Cited by 14 publications

(26 citation statements)

References 6 publications

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Section: Resultsmentioning

confidence: 99%

“…A RV reserve of 0 l implies the hydrostatically induced lung compression at maximum depth led to a reduction in lung volume that was equivalent to RV. For comparison, patients with varying lung diseases have been previously reported to exhibit O 2 deficits ranging between 24 and 71 mmHg (West et al, 2018) TA B L E 6 Role of body position on pulmonary gas exchange inefficiency (Study 2) Data are means ± SD in 17 divers all time points, unless otherwise noted (n). * P < 0.05 from baseline.…”

Section: F I G U R Ementioning

confidence: 99%

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Temporal changes in pulmonary gas exchange efficiency when breath‐hold diving below residual volume

Patrician

Spajić

Gasho

et al. 2021

Experimental Physiology

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Breath-hold diving involves highly integrative and extreme physiological responses to both exercise and asphyxia during progressive elevations in hydrostatic pressure. Over two diving training camps (Study 1 and 2), 25 breath-hold divers (recreational to worldchampion) performed 66 dives to 57 ± 20 m (range: 18-117 m). Using the deepest dive from each diver, temporal changes in cardiopulmonary function were assessed using non-invasive pulmonary gas exchange (indexed via the O 2 deficit), ultrasound B-line scores, lung compliance and pulmonary haemodynamics at baseline and following the dive. Hydrostatically induced lung compression was quantified in Study 2, using spirometry and lung volume measurement, enabling each dive to be categorized by its residual volume (RV)-equivalent depth. From both studies, pulmonary gas exchange inefficiency-defined as an increase in O 2 deficit-was related to the depth of the dive (r 2 = 0.345; P < 0.001), with dives associated with lung squeeze symptoms exhibiting the greatest deficits. In Study 1, although B-lines doubled from baseline (P = 0.027), cardiac output and pulmonary artery systolic pressure were unchanged post-dive. In Study 2, dives with lung compression to ≤RV had higher O 2 deficits at 9 min, compared to dives that did not exceed RV (24 ± 25 vs. 5 ± 8 mmHg; P = 0.021). The physiological significance of a small increase in estimated lung compliance post-dive (via decreased and increased/unaltered airway resistance and reactance, respectively) remains equivocal. Following deep dives, the current study highlights an integrated link between hydrostatically induced lung compression and transient impairments in pulmonary gas exchange efficiency.

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Section: Resultsmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Temporal changes in pulmonary gas exchange efficiency when breath‐hold diving below residual volume

Patrician

Spajić

Gasho

et al. 2021

Experimental Physiology

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“…A-aDO 2 and RI can evaluate the pulmonary ventilation function reliably. In addition, A-aDO 2 is a sensitive indicator of pulmonary diffusion function and pulmonary gas exchange e ciency in the early stage of ventilation insu ciency [24,25]. OI indicates the lung ventilation function and oxygen utilization, is directly proportional to lung function.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Electrical Acupoint Stimulation Attenuates Lung Injury Caused by Tourniquet-induced Limb Ischemia/reperfusion During Lower Extremity Surgery: A Randomized Controlled Trial

Gong

Zhao

et al. 2020

Preprint

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Background: Tourniquet-induced extremity ischemia-reperfusion injury is one of the major complications in patients with lower extremity surgery, while lung is the most vulnerable organ to insult subsequent to ischemia-reperfusion. Current scientific research data has shown that electric stimulation at special acupoints could suppress inflammasome activation and subsequently exert protective effects in the lungs. Thus, the effect of transcutaneous electrical acupuncture point stimulation (TEAS) on lung injury induced by limb ischemia/reperfusion remains to be elucidated. Methods: One hundred individuals scheduled for unilateral lower extremity surgery were randomly divided into 2 groups (n=50 each): transcutaneous electrical acupoint stimulation group (group T) and control group (group C). Patients in group T were given TEAS at FeiShu (BL13, bilateral) acupoints and ZuSanLi (ST36, non-surgical side) acupoint, while patients in group C received sham stimulation (no current) at the same acupoints for the same time as the TEAS group. Arterial blood samples were collected to assess blood gas analysis and other indicators. Results: The TEAS group showed significant improvements in blood gas analysis. Compared with group C, PaO2 and oxygenation index (OI) in group T were significantly increased at T4(4h after removing the tourniquet), while A-aDO2 and respiratory index (RI) were decreased at T4. There was an increase in the HO-1 levels in group T at T3(2h after removing the tourniquet) and T4 compared with group C. Compared with group T, SOD levels were signiﬁcantly lower at T4 in group C. At T4, the levels of ICAM-1, IL-6 and IL8 were significantly lower in group T when compared to group C. At T3 and T4, IL-10 levels were higher when compared to group C, while TNF-a levels were significantly lower.Conclusions: Transcutaneous electrical acupoint stimulation attenuates lung injury following tourniquet-induced extremity ischemia-reperfusion in patients, and HO-1 is endowed of potential mechanism of cytoprotective effects against tourniquet-induced lung injury. Trial registration: Chinese Clinical Trial Registry, ChiCTR-IOR-16008264. Registered 11 April 2016, http://www.chictr.org.cn/ ChiCTR-IOR-16008264

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“…With this goal in mind, the value of a simpler non-invasive method to estimate gas exchange efficiency may outweigh the potential differences in alveolar and end-tidal CO 2 that could possibly be more readily observed with direct measurements of arterial blood gas or using the multiple inert gas elimination technique. If pulmonary vasodilator therapy is to be employed for a larger population of mild COPD patients to increase their exercise capacity, the method of West et al (2018) would be a much more practical way of assessing gas exchange.…”

mentioning

confidence: 99%

“…If pulmonary vasodilator therapy is to be employed for a larger population of mild COPD patients to increase their exercise capacity, the method of West et al . (2018) would be a much more practical way of assessing gas exchange.…”

mentioning

confidence: 99%

Improving gas exchange and exercise tolerance in mild COPD patients

Sieck¹,

Sieck

2021

The Journal of Physiology

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A New, Noninvasive Method of Measuring Impaired Pulmonary Gas Exchange in Lung Disease: An Outpatient Study

Cited by 14 publications

References 6 publications

Temporal changes in pulmonary gas exchange efficiency when breath‐hold diving below residual volume

Temporal changes in pulmonary gas exchange efficiency when breath‐hold diving below residual volume

Transcutaneous Electrical Acupoint Stimulation Attenuates Lung Injury Caused by Tourniquet-induced Limb Ischemia/reperfusion During Lower Extremity Surgery: A Randomized Controlled Trial

Improving gas exchange and exercise tolerance in mild COPD patients

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