A new option for the reconstruction of orbital floor defects with heterologous cortical bone

Özel, Begüm; Fındıkçıoğlu, Kemal; Sezgin, Billur; Güney, Kırdar; Barut, Ismail; Özmen, Selahattin

doi:10.1016/j.jcms.2015.06.029

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…While orthopaedic literature has limited reports of xenograft use, facial reconstruction and periodontal literature has more experience with these products [ 25 , 26 , 27 , 28 , 29 ]. The biology of oral and facial grafting sites differs from sites of orthopaedic pathology treated with bone grafting but it is still important to recognize the recent successes seen with xenografts and various bone graft substitutes used in treatment of facial and periodontal pathology [ 30 , 31 , 32 ] with improved patient outcomes and quality of life [ 25 , 26 ]. This literature supports further consideration in orthopaedic applications as well.…”

Section: Introductionmentioning

confidence: 99%

A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure

Bracey

Seyler

Jinnah

et al. 2018

JFB

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Background: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bone graft include allografts, synthetics and, less commonly, xenografts which are taken from animal species. Xenografts are available in unlimited supply from healthy animal donors with controlled biology, avoiding the risk of human disease transmission, and may satisfy current demand for bone graft products. Methods: In the current study, cancellous bone was harvested from porcine femurs and subjected to a novel decellularization protocol to derive a bone scaffold. Results: The scaffold was devoid of donor cellular material on histology and DNA sampling (p < 0.01). Microarchitectural properties important for osteoconductive potential were preserved after decellularization as shown by high resolution imaging modalities. Proteomics data demonstrated similar profiles when comparing the porcine bone scaffold against commercially available human demineralized bone matrix approved for clinical use. Conclusion: We are unaware of any porcine-derived bone graft products currently used in orthopaedic surgery practice. Results from the current study suggest that porcine-derived bone scaffolds warrant further consideration to serve as a potential bone graft substitute.

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Section: Introductionmentioning

confidence: 99%

A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure

Bracey

Seyler

Jinnah

et al. 2018

JFB

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“…Although undeniable progress in the management of orbital floor fractures has occurred over the past decades, there is still a lack of broad consensus as to which material(s) should be used to restore proper anatomy of the orbital floor in order to achieve best clinical results. This is also reflected by the still very high number of recent studies describing various approaches and materials to reconstruct the orbital floor, such as titanium meshes [27], partially absorbable meshes [28], bioresorbable implants [29,30], resorbable collagen membranes [31], polydioxanone foils [32], porous polyethylene sheets [33], bioactive glass S53P4 implants [34], auricular conchal grafts [35], rib bone grafts [36], or heterologous cortical bone [37].…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome Following Surgical Repair of Small Versus Large Orbital Floor Fractures Using Polyglactin 910/Polydioxanone (Ethisorb®)

et al. 2020

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The aim of this retrospective study was to evaluate the clinical outcome of surgical management of small versus large, isolated orbital floor fractures (OFFs) using polyglactin 910/polydioxanone (Ethisorb®). Covering a four-year period (2010–2013), all records concerning midfacial fractures with involvement of the orbit were screened. Isolated fractures of the orbital floor as well as combined injuries of the orbital floor and medial wall that had been treated surgically using polyglactin 910/polydioxanone (Ethisorb®) were included. Patients underwent a preoperative, a postoperative, and a late ophthalmologic assessment. The clinical outcomes of surgically managed small OFFs up to 2 cm2 were statistically analyzed and compared to clinical results in larger defects. The final sample included 61 patients (25 women, 36 men). Fractures up to 2 cm2 were found in 33 patients (54.1%), whereas 28 patients (45.9%) suffered from OFFs larger than 2 cm2. The clinical outcomes did not significantly differ between both sample categories, and statistical analysis showed a power of 0.91 to detect a potentially existing difference. On final examination, 52 patients were free of any clinical symptoms, whereas minor issues were found in seven subjects, and two patients suffered from severe impairment. In conclusion, polyglactin 910/polydioxanone (Ethisorb®) seems to be a suitable material for surgical repair of both small and large OFFs.

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“…Bone blocks, cortical laminas, and membranes of heterologous cortical bone have been used successfully in recent years in plastic and maxillofacial surgery due to their plasticity and biocompatible structure and may be a less morbid alternative to distance block grafting. Being all of them resorbable is another advantage when compared to nonresorbable membranes and barriers [7, 8].…”

Section: Discussionmentioning

confidence: 99%

Guided Bone Regeneration of an Atrophic Maxilla Using Heterologous Cortical Lamina

Polis-Yanes

Cadenas-Sebastián

Gual-Vaqués

et al. 2019

Case Reports in Dentistry

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Alloplastic dental implants are currently the best way to replace lost teeth. In order to achieve good function and prognosis of dental implants, having bone and soft tissue to support them is necessary. When the amount of bone left is not enough to ensure the outcome of the implant, techniques such as shorts implants, zygomatic implants, or guided bone regeneration have been used. Even though autologous bone is mostly the “gold standard,” other biomaterials such as xenografts have led to the reduction of the morbidity of treatments and to the improvement of the regeneration technique outcomes. We present a clinical case of severe atrophy of the maxilla in which we used different types of biomaterials: heterologous cortical lamina, xenograft and autologous bone, and microscrews.

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A new option for the reconstruction of orbital floor defects with heterologous cortical bone

Cited by 6 publications

References 24 publications

A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure

A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure

Clinical Outcome Following Surgical Repair of Small Versus Large Orbital Floor Fractures Using Polyglactin 910/Polydioxanone (Ethisorb®)

Guided Bone Regeneration of an Atrophic Maxilla Using Heterologous Cortical Lamina

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