A New Oxygenated Tricyclic Sesquiterpene from a Soft Coral of Nephthea Species of Andaman and Nicobar Coasts of Indian Ocean.

Rao, C. Radhakrishna; Sekhar, V. Chandra; Sarvani, B.; Rao, D. V. G. L. N.

doi:10.1002/chin.200442198

Cited by 5 publications

(7 citation statements)

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“…The compounds 1 and 2 were trans and cis isomers, but downfield shifts were observed at H-1β in 1 and 2 , and H-10β in 2 . The downfield shifts of both cyclopropane methines for 2 (δH 1.45 and 1.38) were similar to those observed in cyclocolorenone (δH 1.54 and 1.29) and its derivative [13,14]. It is reported that this cyclocolorenone also has one double bond beside these cyclopropane methines similar to those of 1 and 2 , where the double bond was located at C2/C3.…”

Section: Resultssupporting

confidence: 71%

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

Phan

Kim

et al. 2015

Marine Drugs

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Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

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Section: Resultssupporting

confidence: 71%

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

Phan

Kim

et al. 2015

Marine Drugs

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“…This tricyclic sesquiterpene was earlier isolated from different members of the genus Nephthea, eg, N. chabrolii AUDOIN. 72 Additionally, another nardosinane sesquiterpene with the molecular formula C 15 H 22 O 2 , in good agreement with the mass ion peak at m/z 233.154, was characterized as lemnalactone (4). This compound was firstly identified from the soft coral Paralemnalia digitiformis Macfadyen.…”

Section: Ftir Characterization Of the Synthesized Snpsmentioning

confidence: 54%

<p>Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral <em>Nephthea</em> Sp. Supported by Metabolomics Analysis and Docking Studies</p>

Abdelhafez

Ali

Fahim

et al. 2020

IJN

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Background: Soft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential as source of anti-inflammatory metabolites has stimulated a growing research interest. Purpose: To investigate the anti-inflammatory potential of the soft coral, Nephthea sp., in its bulk and silver nanostructure. Metabolomics analysis of Nephthea sp., followed by molecular docking studies, was also conducted in order to explore and predict the secondary metabolites that might provide its inhibitory actions on inflammation. Materials and Methods: The petroleum ether and ethyl acetate fractions were used to synthesize silver nanoparticles. The prepared silver nanoparticles were characterized through UV-vis spectrophotometric, transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR) analyses. Testing for the anti-inflammatory activity was performed against COX-1 and COX-2. Furthermore, liquid chromatography-mass spectrometry (LC-MS) based metabolomics analysis and molecular docking were also applied. Results: A variety of secondary metabolites were identified, among them, sesquiterpenes were found to prevail. The petroleum ether and acetone fractions of Nephthea sp. showed the highest COX-2 inhibitory activities, possibly attributable to their substantial contents of terpenoids. Additionally, the green synthesized silver nanoparticles of both the petroleum ether and ethyl acetate fractions of Nephthea sp. demonstrated higher anti-COX-2 properties. Conclusion: The obtained results showed the effectiveness of non-targeted metabolomics technique in metabolic profiling of Nephthea sp., helping the search for new bioactive metabolites in future chemical studies on this soft coral. The interesting anti-inflammatory potential of the tested extracts and their nanoparticles could also be relevant to the development of new, effective anti-inflammatory agents.

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“…The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR, and ESI-MS, together with comparison with those previously reported in the literature. On the other hand, the oxygenated tricyclic sesquiterpene, cyclocolorenone (1) has been isolated so far from terrestrial liverworts [13][14][15], terrestrial plants [16,17], and the soft coral Nephthea species [18,19]. This is the first time that the isolation of (+)-cyclocolorenone (1) has been reported from marine algae.…”

Section: Present Studymentioning

confidence: 95%

Investigation of Insect Repellent Activity of Cyclocolorenone Obtained from the Red Alga Laurencia intricata

Ishii¹,

Shinjo²,

Miyagi³

et al. 2018

Rec.Nat.Prod.

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Three known secondary metabolites were isolated from the organic extract of Laurencia intricata. Their structures were identified by NMR and MS experiments and comparison with the literature data. An aromadendrane sesquiterpene, (+)-cyclocolorenone showed strong repellent activity against the maize weevil Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) adults. It had the same activity as natural insecticides, pyrethrins, with a ED50 value of 2.0 g/cm 2 . This is the first report of insect repellent activity of (+)cyclocolorenone. The results suggest that the red alga Laurencia is a promising source of bioactive compounds which can be used as potential biocontrol agents for stored-product insects.

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A New Oxygenated Tricyclic Sesquiterpene from a Soft Coral of Nephthea Species of Andaman and Nicobar Coasts of Indian Ocean.

Abstract: From the ethanol extract of the title coral the novel compound (I) together with a known substance is isolated. -(RAO, C. B.; SEKHAR, V. C.; SARVANI, B.; RAO*, D. V.; Indian J.

Cited by 5 publications

References 0 publications

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

<p>Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral <em>Nephthea</em> Sp. Supported by Metabolomics Analysis and Docking Studies</p>

Investigation of Insect Repellent Activity of Cyclocolorenone Obtained from the Red Alga Laurencia intricata

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