A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

Wang, Qiang; Yang, Xue‐Qiong; Miao, Cui‐Ping; Xu, Li-Hua; Ding, Zhong‐Tao; Yang, Ya‐Bin; Zhao, Li‐Xing

doi:10.25135/rnp.12.17.04.065

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…In this work, mellein ( 1 ) showed moderate antifungal effects against F. oxysporum, A. alternata, and B. cinerea . Similarly, previous reports showed moderate activity of 1 against B. cinerea [ 19 , 39 , 40 ], F. oxysporum, and F. solani [ 41 ]. Mellein ( 1 ) also showed potent ixodicidal effects against larvae of the hard tick Hyalomma lusitanicum .…”

Section: Discussionsupporting

confidence: 76%

Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2

Morales-Sánchez

Díaz

Trujillo

et al. 2021

JoF

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In the current study, an ethyl acetate extract from the endophytic fungus Aspergillus sp. SPH2 isolated from the stem parts of the endemic plant Bethencourtia palmensis was screened for its biocontrol properties against plant pathogens (Fusarium moniliforme, Alternaria alternata, and Botrytis cinerea), insect pests (Spodoptera littoralis, Myzus persicae, Rhopalosiphum padi), plant parasites (Meloidogyne javanica), and ticks (Hyalomma lusitanicum). SPH2 gave extracts with strong fungicidal and ixodicidal effects at different fermentation times. The bioguided isolation of these extracts gave compounds 1–3. Mellein (1) showed strong ixodicidal effects and was also fungicidal. This is the first report on the ixodicidal effects of 1. Neoaspergillic acid (2) showed potent antifungal effects. Compound 2 appeared during the exponential phase of the fungal growth while neohydroxyaspergillic acid (3) appeared during the stationary phase, suggesting that 2 is the biosynthetic precursor of 3. The mycotoxin ochratoxin A was not detected under the fermentation conditions used in this work. Therefore, SPH2 could be a potential biotechnological tool for the production of ixodicidal extracts rich in mellein.

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Section: Discussionsupporting

confidence: 76%

Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2

Morales-Sánchez

Díaz

Trujillo

et al. 2021

JoF

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“…In this work, mellein (1) showed moderate antifungal effects against F. oxysporum, A. alternata and B. cinerea. Similarly,previous reports showed moderate activity of 1 against B. cinerea [44,19,45], F. oxysporum and F. solani [46]. Mellein (1) also showed potent ixodicidal effects against larvae of the hard tick Hyalomma lusitanicum.…”

Section: Discussionsupporting

confidence: 72%

Bioactive Metabolites from the Endophytic Fungus <em>Aspergillus sp. </em>SPH2

Morales-Sánchez¹,

Díaz²,

Trujillo³

et al. 2020

Preprint

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In the current study, an ethyl acetate extract from the endophytic fungus Aspergillus ochraceus SPH2 isolated from the stem parts of the endemic plant Bethencourtia palmensis was screened for its biocontrol properties against plant pathogens (Fusarium moniliforme, Alternaria alternata and Botrytis cinerea), insect pests (Spodoptera littoralis, Myzus persicae, Rhopalosiphum padi), plant parasites (Meloidogyne javanica) and ticks (Hyalomma lusitanicum). SPH2 gave extracts with strong fungicidal and ixodicidal effects at different fermentation times. The bioguided isolation of these extracts gave compounds 1-3. Mellein (1) showed strong ixodicidal effects and was also fungicidal. This is the first report on the ixodicidal effects of 1. Neoaspergillic acid (2) showed potent antifungal effects. Compound 2 appeared during the exponential phase of the fungal growth while neohydroxyaspergillic acid (3) appeared during the stationary phase, suggesting that 2 is the biosynthetic precursor of 3. Additional molecular ions compatible with pyrazynes that were detected during the exponential phase included flavacol, and aspergilliamide while ochramide A was mostly detected during the stationary phase of the fermentation. Moreover, polyketids were also detected during the sationaty phase of the fermentation curve (dihydroaspyrone, aspyrone, asperlactone) and the alkaloid circumdatin H. Ochratoxin A was not detected. Therefore, SPH2 could be a potential biotechnological tool for the production of ixodicidal mellein.

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“… 115 Two new aspinotriol derivatives 534 – 535 ( Figure 8B and C ) determined as melleusin A 534 , B 535 were isolated from a soil-borne fungus Aspergillus melleus . 161 A new diphenyl ether 3-methylpentyl-2, 4-dichloroasterrate 536 ( Figure 8C ), was isolated from the metabolites of a wetland fungus Aspergillus flavipes . PJ03-11.…”

Section: Structure Types Of New Compounds Derived From Soil Fungimentioning

confidence: 99%

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Zhang¹,

Li²,

Fan³

et al. 2022

DDDT

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The secondary metabolites isolated from soil fungi have received more and more attention, especially new compounds that exhibited good biological activities. In this review, a total of 546 new compounds are included in the relevant literature since 2011. The new compounds are isolated from soil fungi, We divided these compounds into seven categories, including alkaloids, terpenoids, steroids, ketones, phenylpropanoids, quinones, esters, lactones, etc. In addition, the biological activities and structure–activity relationships of these compounds have also been fully discussed. The activities of these compounds are roughly divided into eight categories, including anticancer activity, antimicrobial activity, anti-inflammatory activity, antioxidant activity, antiviral activity, antimalarial activity, immunosuppressive activity and other activities. Since natural products are an important source of new drugs, this review may have a positive guiding effect on drug screening.

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A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

Cited by 7 publications

References 8 publications

Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2

Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2

Bioactive Metabolites from the Endophytic Fungus <em>Aspergillus sp. </em>SPH2

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

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