2007
DOI: 10.1186/1471-2466-7-11
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A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance

Abstract: BackgroundSeveral strategies and devices have been designed to protect health care providers from acquiring transmissible respiratory diseases while providing care. In modulating the physical characteristics of the respiratory secretions to minimize the aerosolization that facilitates transmission of airborne diseases, a fundamental premise is that the prototype drugs have no adverse effect on the first line of respiratory defense, clearance of mucus by ciliary action.MethodsTo assess and demonstrate the prima… Show more

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Cited by 8 publications
(4 citation statements)
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“…A mucus layer with strengthened elasticity and high cohesiveness will be more resistant to break, and will form less number of droplets and/or produce fewer droplets of a larger size. This is a concept we described in previous publications [ 44 , 45 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A mucus layer with strengthened elasticity and high cohesiveness will be more resistant to break, and will form less number of droplets and/or produce fewer droplets of a larger size. This is a concept we described in previous publications [ 44 , 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, our research group at the Mucophysiology Laboratory, University of Alberta has been developing a novel non-vaccine strategy, mucomodulation [ 44 , 45 ], that has shown the potential to slow or stop the spread of IRD, potentially saving lives as well as reducing the burden on resources for healthcare systems in rich and poor countries alike.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, it should be noted that the current study has investigated the effect of rheological properties measured under oscillatory shear conditions. In the case of elongational properties, spinnability is known to increase with addition of sodium tetraborate (XLB) [43], i.e. with an increase in the amount of cross linking, indicating that there may be a similar relationship between elongational rheological properties and the emitted bioaerosol droplets.…”
Section: Effect Of Viscoelastic Properties On the Volume Concentratiomentioning
confidence: 98%
“…To date the surface properties of the air-mucus interface, which has a surface tension of ~ 32 mN/m, is still not well understood. Although the tracheal mucus is viscoelastic (non-Newtonian) fluid, 15,129 the presence of surfactants at the air-mucus interface, influences mucus surface properties giving it more viscous behavior.…”
Section: More Viscous Behavior Was Also Observed For Dppc Monolayers mentioning
confidence: 99%