A new patch material for tympanic membrane perforation by trauma: the membrane of a hen egg shell

Jun, Hyung Jin; Oh, Kwang-Jun; Yoo, Jun; Han, Won Gue; Chang, Jiwon; Jung, Hak Hyun; Choi, June

doi:10.3109/00016489.2013.857784

Cited by 37 publications

(27 citation statements)

References 18 publications

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“…The final ESM patch diameter was 5 mm. ESM patches were sterilised with ethylene gas [10]. During the ESM patch application, flaps of the perforation were approximated where possible and the ESM patch was placed in saline for moistening before application.…”

Section: Methodsmentioning

confidence: 99%

“…Eggshell membrane (ESM), routinely used in wound dressings, is another potential patching materials [10]. In a previous study, we reported that the healing ratio of the TM was not significantly different between the ESM patch group and the edge approximation group, but that healing time was significantly shorter in the ESM patch group [10].…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study, we reported that the healing ratio of the TM was not significantly different between the ESM patch group and the edge approximation group, but that healing time was significantly shorter in the ESM patch group [10]. The present study had two main objectives: 1) to investigate the effect of ESM patching of traumatic TM perforation, according to the Griffin's TM perforation grade, and 2) to compare healing time according to the patching time, perforation location, and age in the ESM patch application group.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Effect of Eggshell Membrane Patching for Moderate-to-Large Traumatic Tympanic Membrane Perforation

et al. 2017

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Background and ObjectivesTo evaluate the effect of eggshell membrane (ESM) patching for tympanic membrane (TM) perforation, and to investigate correlations between healing time and age, gender, patching time, perforation size, and perforation location.Subjects and MethodsOne hundred and seventy-five patients diagnosed with traumatic TM perforation at the Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, between January 2008 and October 2013. Patients were divided into two groups, according to perforation edge approximation or ESM patching treatment. Healing time was compared between the group that received perforation edge approximation and the group that received ESM patching. Perforation grade, age, onset, and location were also compared between the two groups.ResultsESM patching significantly improved healing time compared to spontaneous healing, especially in patients with moderate or large traumatic TM perforations (≥grade II). However, patient age, gender, perforation location, and especially timing of procedure, did not significantly affect healing time.ConclusionsESM patching can be a good treatment choice to promote tympanic membrane healing in large traumatic TM perforations.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of Effect of Eggshell Membrane Patching for Moderate-to-Large Traumatic Tympanic Membrane Perforation

et al. 2017

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“…Those patients with no therapy showed a preoperative ABG was 26.1 dB HL, whereas the mean postoperative ABG was 5 dB HL [3]. Some studies of patch materials to treat the TMP are listed in Table 2 [3151617181920]. …”

Section: Discussionmentioning

confidence: 99%

Fibrinogen-Based Collagen Fleece Graft Myringoplasty for Traumatic Tympanic Membrane Perforation

Choi

Song

2016

J Audiol Otol

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Background and ObjectivesThe aim of this study was to investigate how fibrinogen-based collagen fleece (Tachocomb®) graft myringoplasty (FCGM), performed under microscopic guidance, improves both hearing and tympanic membrane tissue repair in patients with traumatic tympanic membrane perforation (TMP).Subjects and MethodsBetween August 2009 and March 2015, a total of 52 patients with traumatic TMP visited the department of otorhinolaryngology at a secondary medical center. Twenty-nine of these underwent FCGM under microscopic guidance in our outpatient clinic. For each patient, we recorded the location and size of the perforation, the time elapsed from the onset of TMP until the myringoplasty, and the hearing level both before and after myringoplasty.ResultsThe TMP closed completely in all cases (29 of 29 patients). After myringoplasty, the postoperative air-bone gap (ABG) differed significantly from the preoperative ABG. Three of the 29 patients (10.3%) experienced complications. Specifically, 2 presented with otorrhea after FCGM, but conservative management led to improvement without recurrence of perforation. One patient showed delayed facial palsy 1 week after the procedure. The condition of this patient also improved and the palsy was not permanent.ConclusionsFCGM may be an effective treatment option in case of traumatic TMP. The procedure requires no hospitalization, and can be used to avoid traditional tympanoplasty.

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“…In the last decade, there have been investigations on new materials such as gelfoam patch, EGF, PGF, TGFb1, PDGF, autocollagen, egg shell membrane, estrogen, and plasminogen in human and animal studies for both acute and chronic TMPs [2,[6][7][8][9][10][11] . Although the efficacy of PRP has been investigated in wound healing [12][13][14][15] , its effects on TMP healing have not yet been investigated in acute TMPs.…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Özgürsoy

Tunçkaşık²,

Tunçkaşık³

et al. 2017

Int Adv Otol

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OBJECTIVE:To assess the efficacy of the application of platelet-rich plasma (PRP) in the healing process of acute tympanic membrane perforations (TMPs). MATERIALS and METHODS:Acute TMPs were made in both the ears of 12 New Zealand rabbits. Plasma gel was applied at the right tympanic membrane (TM) of the same animal until the perforations were closed. The left TM was left untreated. On days 1, 4, 7, 10, 13, 16, 21, 28, and 35, the TMs were monitored to check the closure of perforations. The days of perforation closure for the 2 groups were compared using the paired t-test. The animals were sacrificed 2 months after making the perforations. Seven histopathological parameters were reviewed by 2 blinded pathologists: acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, sclerosis, fibroblastic reaction, and an increase in the thickness of the squamous epithelial layer. The presence or absence of each histological parameter in both groups was compared using the Pearson Chi-square test. RESULTS:The average number of days for closure in the plasma gel group was 12 (range 8-18 days) and that in the control group was 17.7 (range 8-31 days). The difference was statistically significant (p=0.0145). There was no sclerosis or fibroblastic reaction in any of the specimens. No statistically significant difference was seen between the 2 groups with respect to acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, and an increase in thickness of the squamous epithelial layer (p>0.05). CONCLUSION:Platelet-rich plasma fastens TMP closure; in long term, the eventual outcome is both microscopically and macroscopically same for the control as well as study groups in a rabbit traumatic TMP model. We believe that this study will encourage the clinical use of PRP for acute TMPs and trigger clinical studies in this field.

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A new patch material for tympanic membrane perforation by trauma: the membrane of a hen egg shell

Abstract: The healing ratio of the TM showed no significant difference between the two groups, but the time to heal was significantly shorter in the ESM patch group than in the perforation edge approximation group.

Cited by 37 publications

References 18 publications

Analysis of Effect of Eggshell Membrane Patching for Moderate-to-Large Traumatic Tympanic Membrane Perforation

Analysis of Effect of Eggshell Membrane Patching for Moderate-to-Large Traumatic Tympanic Membrane Perforation

Fibrinogen-Based Collagen Fleece Graft Myringoplasty for Traumatic Tympanic Membrane Perforation

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

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