A new PEPPSI type N-heterocyclic carbene palladium(II) complexes and its efficiency as a catalyst for Mizoroki-Heck cross-coupling reactions in water : Synthesis, Characterization and their antimicrobial and Cytotoxic activities

Applications of quinoxaline‐bridged bis(benzimidazolium) salts as ligand sources for the palladium‐catalyzed Suzuki and Heck cross‐coupling reactions in an aqueous medium

“…These new compounds show typical spectroscopic signatures that are in line with those recently reported for other alkyl benzimidazoles. [ 63 ]…”

“…These new compounds show typical spectroscopic signatures that are in S C H E M E 1 LHX/Pd(OAc) 2 catalyzed SM and MH cross-couplings in an aqueous medium F I G U R E 1 Bridged bis((benz)imidazolium) salts used in SM and MH cross-coupling reactions as bis(NHC) precursors line with those recently reported for other alkyl benzimidazoles. [63]…”

Synthesis and a combined experimental/theoretical structural study of a comprehensive set of Pd/NHC complexes witho-,m-, andp-halogen-substituted aryl groups (X = F, Cl, Br, CF3)

“…[33][34][35][36][37][38] Recent studies have highlighted the exceptional potential of M/NHC systems in life sciences and drug design. [39][40][41][42] The ability to introduce electron-withdrawing halogen atoms in general and highly specific F-substituents in particular [43][44][45][46] is undoubtedly highly important for this area of research. However, it is difficult to assess the contribution of each specific group and the position of the substituent since there are only a few examples available without systematic structural diversity (o-, m-, p-).…”

Pd–PEPPSI type complexes bearing unsymmetrical NHC ligand with phenyl‐substituted backbone: Highly efficient catalysts for Heck–Mizoroki and Suzuki–Miyaura cross‐coupling reactions

“…Therefore, to overcome the challenges mentioned above, Organ proposed another class of Pd–NHC complexes (Pd–NHC–PEPPSI, PEPPSI: pyridine‐enhanced precatalyst preparation, stabilization and initiation) in 2006. [ 13 ] Since this pioneering study, NHC–Pd–PEPPSI‐type complexes have been proven to be highly active precatalysts for a variety of cross‐coupling reactions, such as Suzuki−Miyaura, [ 14–18 ] Heck‐Mizoroki, [ 17,19–21 ] Negishi, [ 22,23 ] Sonogashira, [ 19,24–26 ] Buchwald–Hartwig [ 27,28 ] and direct arylation reactions. [ 9,29,30 ]…”

“…Therefore, to overcome the challenges mentioned above, Organ proposed another class of Pd-NHC complexes (Pd-NHC-PEPPSI, PEPPSI: pyridine-enhanced precatalyst preparation, stabilization and initiation) in 2006. [13] Since this pioneering study, NHC-Pd-PEPPSI-type complexes have been proven to be highly active precatalysts for a variety of cross-coupling reactions, such as SuzukiÀMiyaura, [14][15][16][17][18] Heck-Mizoroki, [17,[19][20][21] Negishi, [22,23] Sonogashira, [19,[24][25][26] Buchwald-Hartwig [27,28] and direct arylation reactions. [9,29,30] In one of the studies from our laboratory, we reported the preparation of a new type of bidentate N-heterocyclic carbene enolates (NHCE) and their palladium complexes via transmetallation of silver complexes.…”