2020
DOI: 10.1016/j.drudis.2020.09.038
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A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?

Abstract: Highlights Sepsis is a life-threatening condition caused by the body's response to an infection and is regarded as a global health priority due to the lack of effective treatments available. Microvascular dysfunction is well-established during the early stages of sepsis and accounts for much of the pathology of sepsis/septic shock. Sepsis pathogens bind to major integrins expressed on the vascular endothelium and drugs that block this interaction may provi… Show more

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Cited by 15 publications
(18 citation statements)
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References 100 publications
(135 reference statements)
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“…mechanism to bind to host tissue via the major integrin αVβ3 expressed on the vascular endothelium [9,[19][20][21].…”
Section: Plos Onementioning
confidence: 99%
See 1 more Smart Citation
“…mechanism to bind to host tissue via the major integrin αVβ3 expressed on the vascular endothelium [9,[19][20][21].…”
Section: Plos Onementioning
confidence: 99%
“…However, a novel K403R mutation in the spike protein of SARS-CoV-2 forms a unique Arg-Gly-Asp (RGD) motif outside the ACE2 recognition site. This introduces a potential role for RGD-binding integrins in viral entry through the spike protein [ 9 , 10 ]. The endothelial barrier is highly populated with these integrins, where the major endothelial cell integrin, αVβ3, is capable of recognising a plethora of RGD-containing ligands.…”
Section: Introductionmentioning
confidence: 99%
“…Most of the eight RGD binding integrins are expressed at elevated levels in various cancer types where they contribute to crucial pathophysiological functions in cancer as well as in other diseases, such as neurological disorders [ 36 ], sepsis [ 37 ], fibrosis [ 38 ], cardiovascular diseases [ 39 ], and viral infections [ 40 ]. Since this review focuses exclusively on RGD binding integrins, with respect to other integrin family members, we refer to excellent other reviews [ 32 , 41 , 42 ].…”
Section: Integrin/ecm Cell Adhesion and Signaling Receptorsmentioning
confidence: 99%
“…In contrast, in case of Cilengitide, it is also published that low-dose agonistic action leads to vascular promotion effects and stimulation of VEGF-mediated angiogenesis (see Section 3.2.2 ) [ 27 , 157 ]. Recently, interesting applications of the vascular stabilization effect in immune therapy, cancer treatment, and sepsis have emerged (see Section 6.1 ) [ 27 , 37 , 328 , 330 ].…”
Section: Design and Development Of Rgd-based Integrin Ligands For mentioning
confidence: 99%
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