A new perspective in understanding the dissolution behavior of nifedipine controlled release tablets by NIR spectroscopy with aquaphotomics

Detection and analysis of hyaluronic acid raw materials from different sources by NIR and aquaphotomics

“…Liu et al analyzed the dissolution behavior of nifedipine tablets by the changes in water species during the dissolution of nifedipine tablets. 18 Gao et al used water as a probe to characterize the hygroscopic process of stevia raw materials, 24 and proved that the overall state of solid powder can be analyzed by the shift of water molecules. Based on this property, we can use water as a probe to distinguish between different sources of HA.…”

“…NIR spectroscopy not only reects the characteristics of the molecular structure but also embodies intermolecular or intramolecular interactions. [18][19][20] Therefore, it is a promising idea to use NIR spectroscopy to accurately identify HA from different sources. Aquaphotomics is a new discipline which aims to extract and study the structural information about water by analyzing the interaction between water and light of various frequencies.…”

Evaluation of a Combined MHE-NMPC Approach to Handle Plant-Model Mismatch in a Rotary Tablet Press

“…Process analytical technology (PAT) methods play a crucial role in monitoring a variety of CQAs in order to accomplish this [8,9]. Monitoring and control of CQAs such as tensile strength and tablet porosity are critical as they are linked to dissolution profiles of the manufactured tablets, which are ultimately linked to patient safety and treatment efficacy [12][13][14][15][16]. Tablet tensile strength and dissolution profile are affected by various factors such as particle size, API concentration, and addition of lubricants and glidant [17,18].…”