A new perspective of a well-recognized raw material: Phenolic content, antioxidant and antimicrobial activities and α- and β-acids profile of Brazilian hop (Humulus lupulus L.) extracts

Arruda, Társila Rodrigues; Pinheiro, Patrícia Fontes; Silva, Pollyanna Ibrahim; Bernardes, Patrícia Campos

doi:10.1016/j.lwt.2021.110905

Cited by 45 publications

(51 citation statements)

References 45 publications

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“…Humulones and the other bitter acids are susceptible to a natural isomerization process, by light exposure, use of boiling methods or hops extraction using an aqueous medium of increased pH (7.5–8.5), thus resulting in the formation of iso‐α‐acids [7,12] . In addition, these compounds have been increasingly reported in the literature as some of the main anti‐inflammatory agents in hops, [6,33,36–38] which also corroborate our findings.…”

Section: Resultssupporting

confidence: 89%

“…Factors such as cultivation area, maturation stages and climate are determinants to achieve different lupulin metabolites concentration levels and chemical diversity in hop cultivars extracts [11] . Besides, the production of Brazilian hops has been growing, but there is still a lack of studies on their chemical composition [12] . Thus, it is important to evaluate the differences in the metabolite profile of hop cultivars from Brazil and different geographical origin.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐Inflammatory Markers of Hops Cultivars (Humulus lupulus L.) Evaluated by Untargeted Metabolomics Strategy

Nicácio

Ferreira

Katchborian-Neto

et al. 2022

Chemistry & Biodiversity

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Hops (Humulus lupulus L.) are edible flowers commonly used to add flavour and aroma to beer, besides they have rich chemical diversity and medicinal potential. In this work, an ex vivo anti‐inflammatory assay via the LPS‐induced signalling pathway and metabolomics approaches were performed to evaluate the ability of hops to inhibit the production of prostaglandin E2 (PGE2) inflammatory mediator and analyze which metabolites produced by the nine different hop cultivars are potential anti‐inflammatory markers. Columbus, Chinook and Hallertau Mittelfrüh hop cultivars yielded extracts with PGE2 release inhibition rates of 86.7, 92.5 and 73.5 %, respectively. According to the multivariate statistical analysis, the majority of the metabolites correlated with the activity were prenylated phloroglucinol and phenolic homologs. These results suggest promissory anti‐inflammatory hop metabolites.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory Markers of Hops Cultivars (Humulus lupulus L.) Evaluated by Untargeted Metabolomics Strategy

Nicácio

Ferreira

Katchborian-Neto

et al. 2022

Chemistry & Biodiversity

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“…Likewise, a decrease in the severity of A. solani was observed in this same treatment, which may be due to the increase in these metabolites. Phenolic compounds (such as phenols and flavonoids) are characterized by having antimicrobial activity since they are related to the inhibition of the germination of fungal conidia, since they can inactivate the synthesis of essential amino acids of pathogens [42]. Ghorbanpour and Hadian [43] reported the increase in the content of flavonoids in calluses of the medicinal plant Satureja khuzestanica after the application of CNTs (25-1000 µg mL −1 ) to Gamboge's B5 culture medium.…”

Section: Discussionmentioning

confidence: 99%

Carbon Nanotubes Decrease the Negative Impact of Alternaria solani in Tomato Crop

et al. 2021

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The diseases that attack the tomato crop are a limiting factor for its production and are difficult to control or eradicate. Stem and fruit rot and leaf blight caused by Alternaria solani causes severe damage and substantial yield losses. Carbon nanotubes (CNTs) could be an alternative for the control of pathogens since they have strong antimicrobial activity, in addition to inducing the activation of the antioxidant defense system in plants. In the present study, multi-walled carbon nanotubes were evaluated on the incidence and severity of A. solani. Moreover, to the impact they have on the antioxidant defense system and the photosynthetic capacity of the tomato crop. The results show that the application of CNTs had multiple positive effects on tomato crop. CNTs decreased the incidence and severity of A. solani. Furthermore, CNTs increased the fruit yield of tomato crop and dry shoot biomass. The antioxidant system was improved, since the content of ascorbic acid, flavonoids, and the activity of the glutathione peroxidase enzyme were increased. The net photosynthesis and water use efficiency were also increased by the application of CNTs. CNTs can be an option to control A. solani in tomato crop, and diminish the negative impact of this pathogen.

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“…In general, the strong antimicrobial, antioxidant, and antifungal effectiveness of hop extracts is well documented [12,15,[40][41][42]. The bitter acids, particularly humulone and lupulone, are the main agents of the antibacterial and antifungal effects ( [25], and reference therein).…”

Section: As Medicinal Cropmentioning

confidence: 99%

Hops (Humulus lupulus L.) as a Novel Multipurpose Crop for the Mediterranean Region of Europe: Challenges and Opportunities of Their Cultivation

et al. 2021

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The common hop (Humulus lupulus L.) is a dioecious perennial climbing plant, mainly known for the use of its female inflorescences (cones or, simply, “hops”) in the brewing industry. However, the very first interest towards hops was due to its medicinal properties. Actually, the variety of compounds present in almost all plant parts were (and still are) used to treat or prevent several ailments and metabolic disorders, from insomnia to menopausal symptoms as well as obesity and even cancer. Although hops are predominantly grown for hopping beer, the increasing interest in natural medicine is widening new interesting perspectives for this crop. Moreover, the recent success of the craft beer sector all over the world, made the cultivated hop come out from its traditional growing areas. Particularly, in Europe this resulted in a movement towards southern countries such as Italy, which added itself to the already existing hop industry in Portugal and Spain. In these relatively new environments, a complete knowledge and expertise of hop growing practices is lacking. Overall, while many studies were conducted globally on phytochemistry, bioactivity, and the genetics of hops, results from public research activity on basic hop agronomy are very few and discontinuous as well. The objective of this article is to provide an overview of possible uses, phenology, and agronomic aspects of hops, with specific reference to the difficulties and opportunities this crop is experiencing in the new growing areas, under both conventional and organic farming. The present review aims to fill a void still existing for this topic in the literature and to give directions for farmers that want to face the cultivation of such a challenging crop.

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A new perspective of a well-recognized raw material: Phenolic content, antioxidant and antimicrobial activities and α- and β-acids profile of Brazilian hop (Humulus lupulus L.) extracts

Cited by 45 publications

References 45 publications

Anti‐Inflammatory Markers of Hops Cultivars (Humulus lupulus L.) Evaluated by Untargeted Metabolomics Strategy

Anti‐Inflammatory Markers of Hops Cultivars (Humulus lupulus L.) Evaluated by Untargeted Metabolomics Strategy

Carbon Nanotubes Decrease the Negative Impact of Alternaria solani in Tomato Crop

Hops (Humulus lupulus L.) as a Novel Multipurpose Crop for the Mediterranean Region of Europe: Challenges and Opportunities of Their Cultivation

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