A new player in the beneficial effects of exercise on the aged brain

Llorens‐Martin, María

doi:10.1038/s41392-020-00305-5

Cited by 2 publications

(1 citation statement)

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“…Physical exercise has many beneficial effects on the brain and body. Physical exercise helps maintain the cognitive ability of healthy adults and delays the cognitive decline associated with aging [23]. Accumulating evidence has presented the beneficial effect of exercise on neurodegenerative conditions, including AD and PD [24].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Exercise-Mediated Alteration of miR-192-5p Is Associated with Cognitive Improvement in Alzheimer’s Disease

Qin

Han

Jing

et al. 2021

Neuroimmunomodulation

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Introduction: Physical exercise is an important component of managing Alzheimer’s disease (AD). miRNAs can be modulated by exercise intervention. Objective: The study explored the involvement and potential mechanism of miR-192-5p in the protective effect of physical exercise on AD. Methods: Ninety AD patients were enrolled, in which 45 cases accepted cycling training for continuous 3 months. The expression changes of miR-192-5p before and after exercise were analyzed by reverse transcription-quantitative PCR. 8-month-old APP/PS1 double Tg mice were used as the AD animal model. Mice in the voluntary exercise (VE) group received VE for 4 weeks. Morris water maze (MWM) test was used to evaluate the learning and memory function. Enzyme-linked immunosorbent assay was used to calculate the level of IL-1β, IL-6, and TNF-α. Results: AD patients showed elevated MMSE scores, decreased ADAS-cog and NPI-Q scores after 3 months of exercise. miR-192-5p was downregulated in the serum of AD patients and correlated with the levels of MMSE score, ADAS-cog, and NPI-Q score. A positive association was detected between serum miR-192-5p with TNF-α, IL-6, and IL-1β levels. MiR-192-5p is downregulated in the hippocampus tissues of mice after VE. Overexpression of miR-192-5p reversed the neuroprotective effect of exercise on AD in mice and promoted the inflammatory response of AD mice. Conclusion: MiR-192-5p can be modulated by the exercise intervention and involved in the protective effect of exercise on AD.

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Section: Discussion/conclusionmentioning

confidence: 99%