A New Polyketide from the Endophytic Fungus &lt;i&gt;Penicillium chermesinum&lt;/i&gt;

Darsih, Cici; Prachyawarakorn, Vilailak; Mahidol, Chulabhorn; Ruchirawat, Somsak; Kittakoop, Prasat

doi:10.22146/ijc.22273

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Previous reports, showed that Penicillium genus has many important biological activities (Hyde and Soytong 2008 ). Moreover, Kittakoop’s group discovered a new polyketide (2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6 H -benzo[c]chromen-6-one) from the Penicillium chermesinum which has shown to be cytotoxic against four cancer cell lines, which are HuCCA-1, HepG2, A549 and Moult-3 cell lines (Darsih et al 2017 ). This data supports that the Penicillium sp.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic endophyte from Camellia oleifera Abel - Penicillium chermesinum NR121310

2019

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Ten unknown endophytes were isolated from several parts of Camellia oleifera Abel and their biological activities were studied. One endophyte, Tea2-L1, showed the highest inhibition in various antioxidant capacity assay and cytotoxicity assays. The phylogenetic study suggested that Tea2-L1 endophyte is identified as Penicillium chermesinum NR121310 species. This shows the importance of the Penicillium species as a potential drug source.

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Section: Resultsmentioning

confidence: 99%

Cytotoxic endophyte from Camellia oleifera Abel - Penicillium chermesinum NR121310

2019

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“…Endophytic fungi are microorganisms that live below the epidermal cell layer in plant tissues without causing any symptoms of disease. They form symbiotic relationships with their host plants, producing secondary metabolites that protect against pathogen attacks [ 6 , 7 ]. Substances produced by endophytic fungi have a variety of effects on plants, including growth promotion, increased resistance to disease, and an enhanced ability to withstand environmental stress [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Nematicidal Activity of Grammicin Biosynthesis Pathway Intermediates in Xylaria grammica KCTC 13121BP against Meloidogyne incognita

et al. 2021

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Grammicin, a polyketide metabolite produced by the endolichenic fungus Xylaria grammica KCTC 13121BP, shows strong nematicidal activity against Meloidogyne incognita. This study was performed to elucidate the grammicin biosynthesis pathway of X. grammica KCTC 13121BP and to examine the nematicidal activity of the biosynthesis intermediates and derivatives against M. incognita. Two grammicin biosynthesis intermediates were isolated from a T-DNA insertion transformant (strain TR-74) of X. grammica KCTC 13121BP and identified as 2-(hydroxymethyl)cyclohexa-2,5-diene-1,4-dione (compound 1) and 2,5-dihydroxybenzaldehyde (compound 2), which were also reported to be intermediates in the biosynthesis pathway of patulin, an isomer of grammicin. This indicates that the grammicin biosynthesis pathway overlaps almost with that of patulin, except for the last few steps. Among 13 grammicin biosynthesis intermediates and their derivatives (except grammicin), toluquinol caused the highest M. incognita J2 mortality, with an LC50/72 h value of 11.13 µg/mL, which is similar to grammicin with an LC50/72 h value of 15.95 µg/mL. In tomato pot experiments, the wettable powder type formulations (WP) of toluquinol (17.78 µg/mL) and grammicin (17.78 µg/mL) also effectively reduced gall formation on the roots of tomato plants with control values of 72.22% and 77.76%, respectively, which are much higher than abamectin (16.67%), but lower than fosthiazate (100%). The results suggest that toluquinol can be used directly as a biochemical nematicide or as a lead molecule for the development of new synthetic nematicides for the control of root-knot nematode diseases.

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Bioactive Compounds Produced by Biocontrol Agents Driving Plant Health

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et al. 2019

Microbiome in Plant Health and Disease

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A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>

Abstract: A new polyketide derivative, 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one (1) 2-chloro-3,4,7-trihydroxy-9-methoxy-1-methyl-6H-benzo[c]chromen-6-one. Senyawa 1 menunjukkan aktivitas sitotoksisitas lemah terhadap sel kanker HepG2,71 µM.

Cited by 5 publications

References 24 publications

Cytotoxic endophyte from Camellia oleifera Abel - Penicillium chermesinum NR121310

Cytotoxic endophyte from Camellia oleifera Abel - Penicillium chermesinum NR121310

Nematicidal Activity of Grammicin Biosynthesis Pathway Intermediates in Xylaria grammica KCTC 13121BP against Meloidogyne incognita

Bioactive Compounds Produced by Biocontrol Agents Driving Plant Health

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