A new process for fabricating tip-shaped polymer microstructure array with patterned metallic coatings

Zhou, Hongbo; Li, Gang; Sun, Xiao-Na; Zhu, Zhuanghui; Xu, Buli; Jin, Qinghui; Zhao, Jianlong; Ren, Qiushi

doi:10.1016/j.sna.2009.01.009

Cited by 12 publications

(6 citation statements)

References 31 publications

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“…The application of microneedle arrays in biomedical science ranges from drug delivery to detection of biomarkers [1]. In terms of microneedles fabrication, injection moulding emerged as an alternative process to silicon microfabrication offering advantages towards cost and robustness [2]. In complex systems such as muscles, organs and applications where food chemical heterogeneities have to be measured, in this regard, the microneedles can serve as minimally invasive tools to achieve high-density chemical mapping.…”

Section: Introductionmentioning

confidence: 99%

Injection moulded microneedle sensor for real-time wireless pH monitoring

Mirza

Zuliani

Hou

et al. 2017

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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This paper describes the development of an array of individually addressable pH sensitive microneedles using injection moulding and their integration within a portable device for real-time wireless recording of pH distributions in biological samples. The fabricated microneedles are subjected to gold patterning followed by electrodeposition of iridium oxide to sensitize them to 0.07 units of pH change. Miniaturised electronics suitable for the sensors readout, analog-to-digital conversion and wireless transmission of the potentiometric data are embodied within the device, enabling it to measure real-time pH of soft biological samples such as muscles. In this paper, real-time recording of the cardiac pH distribution, during ischemia followed by reperfusion cycles in cardiac muscles of male Wistar rats has been demonstrated by using the microneedle array.

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Section: Introductionmentioning

confidence: 99%

Injection moulded microneedle sensor for real-time wireless pH monitoring

Mirza

Zuliani

Hou

et al. 2017

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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“…Recently, MEMS processing techniques (41, 42) have been adopted in the manufacture of different visual prostheses in order to improve the spatial resolution. For example, polyimide MEMS-based 60 platinum electrode arrays were adopted in Argus ™ II for epiretinal visual restoration (43).…”

Section: Discussionmentioning

confidence: 99%

“…For example, polyimide MEMS-based 60 platinum electrode arrays were adopted in Argus ™ II for epiretinal visual restoration (43). In addition, different geometric-structures of the MEMS electrode arrays have been fabricated, e.g., the flat, concave, pyramid, and hemispherical MEMS electrode arrays can be fabricated based on flexible polymer substrates (4, 41, 42). Several studies on geometrical factors have indicated that design innovation of stimulating microelectrode arrays (MEAs) would affect the stimulating threshold and greatly change the results of stimulation (9, 11, 14).…”

Section: Discussionmentioning

confidence: 99%

3D Finite Element Modeling of Epiretinal Stimulation: Impact of Prosthetic Electrode Size and Distance from the Retina

et al. 2015

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“…However, the permanent presence of the rigid electrode can induce a mechanical mismatch with soft brain tissues, which is an obstacle to successful long-term implantation [ 44 ]. As an alternative, biodegradable polymers, such as silk fibroin, polyvinyl alcohol (PVA) and polylactic acid-glycolic acid (PLGA), are exploited to make biodegradable electronic devices, but they performed poor mechanical properties [ 46 , 47 ]. As shown in Fig.…”

Section: Application Of Bms In Neurosciencementioning

confidence: 99%

Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials

Jiang

Gao

et al. 2022

Bioactive Materials

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Over the past two decades, biodegradable metals (BMs) have emerged as promising materials to fabricate temporary biomedical devices, with the purpose of avoiding potential side effects of permanent implants. In this review, we first surveyed the current status of BMs in neuroscience, and briefly summarized the representative stents for treating vascular stenosis. Then, inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents, we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke. For these novel applications, some key factors should also be considered in designing BM brain stents, including the anatomic features of the cerebral vasculature, hemodynamic influences, neuro-cytocompatibility and selection of alloying elements. This work may provide insights into the future design and fabrication of BM neurological devices, especially for brain stents.

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A new process for fabricating tip-shaped polymer microstructure array with patterned metallic coatings

Cited by 12 publications

References 31 publications

Injection moulded microneedle sensor for real-time wireless pH monitoring

Injection moulded microneedle sensor for real-time wireless pH monitoring

3D Finite Element Modeling of Epiretinal Stimulation: Impact of Prosthetic Electrode Size and Distance from the Retina

Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials

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