A New Proposed Rodent Model of Chemically Induced Prostate Carcinogenesis: Distinct Time-Course Prostate Cancer Progression in the Dorsolateral and Ventral Lobes

Gonçalves, Bianca F.; Campos, Silvana G. P.; Zanetoni, Cristiani; Scarano, Wellerson Rodrigo; Falleiros, Luiz R.; Amorim, Renée Laufer; Góes, Rejane Maira; Taboga, Sebastião Roberto

doi:10.1002/pros.22669

Cited by 31 publications

(40 citation statements)

References 46 publications

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“…This model has been providing a good alternative to study the alterations that occur in the stromal microenvironment of the prostate gland during carcinogenesis, since it develops spontaneous neoplasias (Pegorin de Campos et al, 2006;Campos et al, 2008;Custodio et al, 2008) and induced neoplasia (Gonç alves et al, , 2013 in a relevant number of individuals, presenting significant responses regarding hormonal treatment (Santos et al, 2006;Scarano et al, 2006Scarano et al, , 2008Oliveira et al, 2007).…”

Section: Animal Models For Prostate Cancermentioning

confidence: 99%

Key participants of the tumor microenvironment of the prostate: An approach of the structural dynamic of cellular elements and extracellular matrix components during epithelial–stromal transition

et al. 2015

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Section: Animal Models For Prostate Cancermentioning

confidence: 99%

Key participants of the tumor microenvironment of the prostate: An approach of the structural dynamic of cellular elements and extracellular matrix components during epithelial–stromal transition

et al. 2015

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“…Similarly, e‐cadherin is inversely correlated with tumor aggressiveness (reviewed by Jeanes et al, ). Areas with loss of e‐cadherin immunostaining and irregular distribution were observed in gerbils with prostate cancer chemically‐induced (Gonçalves et al, ), showing an inverse patterning when compared with animals submitted to TT.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, e-cadherin is inversely correlated with tumor aggressiveness (reviewed by Jeanes et al, 2008). Areas with loss of e-cadherin immunostaining and irregular distribution were observed in gerbils with prostate cancer chemicallyinduced (GonS calves et al, 2013), showing an inverse patterning when compared with animals submitted to TT. Figure 4 Proliferation index (a) and Western blotting analysis of PAR4 (b) in the ventral prostate of Wistar rats submitted or not to testosterone therapy.…”

Section: Discussionmentioning

confidence: 99%

Modulation of inflammatory and hormonal parameters in response to testosterone therapy: Effects on the ventral prostate of adult rats

Mendes

Castilho

Pinho

et al. 2018

Cell Biology International

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Testosterone is often recommended in the treatment of several aging-related conditions. However, there are still questions about the consequences of this therapy in terms of hormonal and inflammatory parameters that are crucial for prostate homeostasis. Thus, we investigate if the testosterone therapy (TT) modulates the hormone receptors and inflammatory cytokines in the ventral prostate of adult rats. Wistar rats aging 150 days were divided into two experimental groups (n = 10/group): T: received subcutaneous injections of testosterone cypionate (5 mg/kg body weight) diluted in corn oil every other day for 4 weeks; and C: received corn oil as vehicle. Animals were euthanized at 180 days old by decapitation. Blood was collected to obtain hormone and cytokines concentrations. The ventral prostate was dissected and processed for light microscope and molecular analyses. Relative ventral prostate weight and epithelial compartment were increased after TT. The number of intact and degranulated mast cells was reduced in the T group. Plasma testosterone, DHT and intraprostatic testosterone concentrations were higher in the T group. TT leads to an increase in cell proliferation and up-regulation of AR, ERβ, PAR-4, and NRF2. Importantly, plasma concentration and tissue expression of IL-10 and TNF-α were higher after TT. In summary, these results indicate that TT can regulate inflammatory response, with impacts in cytokines and mast cell population, and modulates steroids receptors, important parameters for prostatic homeostasis.

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“…Thus, high MGMT immunostaining suggests tissue areas with higher DNA methylation. On the other hand, methyltransferases depletion results in the maintenance of methylation sites, which are potentially mutagenic . Prostatic epigenetic changes induced by parabens were not reported for the scientific literature.…”

Section: Discussionmentioning

confidence: 99%

Endocrine‐disrupting effects of methylparaben on the adult gerbil prostate

Costa

Campos

Lima

et al. 2017

Environmental Toxicology

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Parabens are xenoestrogens widely employed in cosmetics, foodstuffs, and pharmaceutical products. These chemicals are known to disrupt hormone-dependent organs, due to their binding affinity for hormonal receptors. Although recent studies have evaluated the endocrine-disrupting potential of parabens in several reproductive organs, few have investigated the effects of these chemicals in the prostate. The aim of this work was to evaluate the effects of oral exposure to methylparaben (500 mg/kg/day) for 3, 7, and 21 days on male and female adult gerbil prostate. For this purpose, we employed biometrical, morphological, and immunohistochemical analyses. The results showed that methylparaben caused morphological changes in gerbil prostates in all experimental groups. These animals displayed similar alterations such as prostate epithelial hyperplasia, increased cell proliferation, and a higher frequency of AR-positive cells. However, the prostate of the female gerbil showed additional changes such as stromal inflammatory infiltration, intraepithelial neoplasia foci, and an increase in AR-positive frequency. Altogether, these data show that methylparaben was responsible for disrupting estrogenic and androgenic receptors, suggesting that parabens may have estrogenic and antiandrogenic effects in the prostate.

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A New Proposed Rodent Model of Chemically Induced Prostate Carcinogenesis: Distinct Time-Course Prostate Cancer Progression in the Dorsolateral and Ventral Lobes

Abstract: There are distinct pathways involved in tumor progression in gerbil prostate lobes. This animal provides a good model for prostate cancer since it allows the investigation of advanced steps of carcinogenesis with shorter latency periods in both lobes.

Cited by 31 publications

References 46 publications

Key participants of the tumor microenvironment of the prostate: An approach of the structural dynamic of cellular elements and extracellular matrix components during epithelial–stromal transition

Key participants of the tumor microenvironment of the prostate: An approach of the structural dynamic of cellular elements and extracellular matrix components during epithelial–stromal transition

Modulation of inflammatory and hormonal parameters in response to testosterone therapy: Effects on the ventral prostate of adult rats

Endocrine‐disrupting effects of methylparaben on the adult gerbil prostate

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