A new quantitative index of lobar air trapping in chronic obstructive pulmonary disease (COPD): Comparison with conventional methods

Nagatani, Yukihiro; Murata, Kiyoshi; Takahashi, Masashi; Nitta, Norihisa; Nakano, Yasutaka; Sonoda, Akinaga; Otani, Hideji; Okabe, Hidetoshi; Ogawa, Emiko

doi:10.1016/j.ejrad.2014.12.018

Cited by 8 publications

(12 citation statements)

References 29 publications

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“…These inconsistent results may be due to differences in respiration levels corresponding to the “suspected” end-expiratory phase. In fact, for the assessment of lobar air trapping, MLD changes from end inspiration to end expiration corrected with the LV decrease were reported to be important 36. Compared with the previous reports using static inspiratory and expiratory CT scans, the abnormal collapse of the proximal airway during early expiration on dynamic-ventilation CT was first correlated with the airflow limitation in this study.…”

Section: Discussionmentioning

confidence: 51%

Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients

Nagatani

Hashimoto

Nitta

et al. 2018

COPD

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PurposeThe purpose of this study was to measure changes in lung density and airway dimension in smokers in the lateral position using four-dimensional dynamic-ventilation computed tomography (CT) during free breathing and to evaluate their correlations with spirometric values.Materials and methodsPreoperative pleural adhesion assessments included dynamic-ventilation CT of 42 smokers (including 22 patients with COPD) in the lateral position, with the unoperated lung beneath (dependent lung). The scanned lungs’ mean lung density (MLD) and the bilateral main bronchi’s luminal areas (Ai) were measured automatically (13–18 continuous image frames, 0.35 seconds/frame). Calculations included cross-correlation coefficients (CCCs) between the MLD and Ai time curves, and correlations between the quantitative measurements and spirometric values were evaluated by using Spearman’s rank coefficient.ResultsThe ΔMLD1.05 (from the peak inspiration frame to the third expiratory frame, 1.05 seconds later) in the nondependent lung negatively correlated with FEV1/FVC (r=−0.417, P<0.01), suggesting that large expiratory movement of the nondependent lung would compensate limited expiratory movement of the dependent lung due to COPD. The ΔAi1.05 negatively correlated with the FEV1/FVC predicted in both the lungs (r=−0.465 and −0.311, P<0.05), suggesting that early expiratory collapses of the main bronchi indicate severe airflow limitation. The CCC correlated with FEV1/FVC in the dependent lung (r=−0.474, P<0.01), suggesting that reduced synchrony between the proximal airway and lung occurs in patients with severe airflow limitation.ConclusionIn COPD patients, in the lateral position, the following abnormal dynamic-ventilation CT findings are associated with airflow limitation: enhanced complementary ventilation in the nondependent lung, early expiratory airway collapses, and reduced synchrony between airway and lung movements in the dependent lung.

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Section: Discussionmentioning

confidence: 51%

Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients

Nagatani

Hashimoto

Nitta

et al. 2018

COPD

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“…Additional composite volume and density measurements can be obtained from paired inspiratory/expiratory scans (98).…”

Section: Measurement Of Emphysema and Air Trapping For Phenotypic Chamentioning

confidence: 99%

Lung densitometry: why, how and when

Mascalchi¹,

Camiciottoli²,

Diciotti

2017

J. Thorac. Dis.

102

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Lung densitometry assesses with computed tomography (CT) the X-ray attenuation of the pulmonary tissue which reflects both the degree of inflation and the structural lung abnormalities implying decreased attenuation, as in emphysema and cystic diseases, or increased attenuation, as in fibrosis. and with pulmonary fibrosis. It has also been applied to assess prevalence of smoking-related emphysema and to monitor progression of smoking-related emphysema, alpha1 antitrypsin deficiency emphysema, and pulmonary fibrosis. Finally, it is recommended as end-point in pharmacological trials of emphysema and lung fibrosis.

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“…The manner in which tissue inside the lung expands and contracts throughout the breathing cycle is known to be an indicator of disease, for example gas trapping in COPD. Comparison of the inspiratory and expiratory scans can therefore be exploited as a means of making localized measurements of disease 32 . Our proposed technique makes it possible to study how the shape of the bronchial tree changes during the breathing cycle and offers the potential to be a new method for the identification of localized areas of disease, such as gas trapping.…”

Section: Discussionmentioning

confidence: 99%

Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease

Belchí

Pirashvili

Conway

et al. 2018

Sci Rep

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Quantitative features that can currently be obtained from medical imaging do not provide a complete picture of Chronic Obstructive Pulmonary Disease (COPD). In this paper, we introduce a novel analytical tool based on persistent homology that extracts quantitative features from chest CT scans to describe the geometric structure of the airways inside the lungs. We show that these new radiomic features stratify COPD patients in agreement with the GOLD guidelines for COPD and can distinguish between inspiratory and expiratory scans. These CT measurements are very different to those currently in use and we demonstrate that they convey significant medical information. The results of this study are a proof of concept that topological methods can enhance the standard methodology to create a finer classification of COPD and increase the possibilities of more personalized treatment.

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A new quantitative index of lobar air trapping in chronic obstructive pulmonary disease (COPD): Comparison with conventional methods

Cited by 8 publications

References 29 publications

Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients

Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients

Lung densitometry: why, how and when

Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease

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