Diffusion in the Ti-Al-V system is studied and a CALculation of Phase Diagrams (CALPHAD) diffusion mobility description is developed. Diffusion couple experiments are performed to obtain diffusion paths in the hcp phase at 923 K, 1023 K and 1123 K. The diffusion coefficient of V in the hcp-Ti phase is found to decrease with increasing Al alloying. A forward-simulation analysis is used to evaluate the impurity diffusion coefficient for Al and V diffusion in the hcp Ti-V and the Ti-Al systems which are used as input in the mobility modeling. The composition dependency for the diffusion in the hcp phase in the ternary system is accounted for and a CALPHAD diffusion mobility description is obtained by directly optimizing the mobility parameters as a function of the experimental composition profiles from the diffusion couples. Both experimental data and previous diffusion mobility descriptions in the literature for the bcc Ti-Al-V phase are adopted. A complete description of diffusion in both the hcp and bcc phases for the Ti-Al-V system is presented with the aim to be used for design of Ti alloys and processes. Keywords CALPHAD Á diffusion couples Á diffusion modeling Á interdiffusion Á Ti-Al-V This invited article is part of a special issue of the Journal of Phase Equilibria and Diffusion in honor of Prof. Zhanpeng Jin's 80th birthday. The special issue was organized by Prof. Ji-Cheng (JC) Zhao,