A new reproducible model of an epidural mass lesion in rodents. Part I: Characterization by neurophysiological monitoring, magnetic resonance imaging, and histopathological analysis

Burger, Ralf; Bendszus, Martin; Vince, Giles Hamilton; Roosen, K.; Marmarou, Anthony

doi:10.3171/jns.2002.97.6.1410

Cited by 24 publications

(11 citation statements)

References 67 publications

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“…The baseline ptiO 2 values were more heterogeneous and somewhat lower when compared to previous studies (Burger et al, 2002). Whether or not this may reflect some degree of local tissue damage or irritation is questionable, since there were no signs of tissue injury beside the probe track on brain sections.…”

Section: Methods Of Occlusionmentioning

confidence: 71%

Comparison of different intravascular thread occlusion models for experimental stroke in rats

Woitzik

Schneider

Thomé

et al. 2006

Journal of Neuroscience Methods

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Section: Methods Of Occlusionmentioning

confidence: 71%

Comparison of different intravascular thread occlusion models for experimental stroke in rats

Woitzik

Schneider

Thomé

et al. 2006

Journal of Neuroscience Methods

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“…Experimental studies have been performed with epidural balloon inflation, epidural hematoma, or ischemia models to study the physiological, histopathological and biochemical changes in the brain parenchyma that are caused by brain displacement or intracranial hypertension 15–18 . Although many clinical trials have focused on dysfunction of the hypothalamic-pituitary axis caused by TBI 10, 19–21 , few studies have paid close attention to neuroendocrine and physiopathological alterations of the hypothalamic-pituitary axis induced by TBI in the acute phase.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the role of intracranial hypertension and stress on hippocampal cell apoptosis and hypothalamic-pituitary dysfunction after TBI

Tan

Yang

et al. 2017

Sci Rep

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In recent years, hypopituitarism caused by traumatic brain injury (TBI) has been explored in many clinical studies; however, few studies have focused on intracranial hypertension and stress caused by TBI. In this study, an intracranial hypertension model, with epidural hematoma as the cause, was used to explore the physiopathological and neuroendocrine changes in the hypothalamic–pituitary axis and hippocampus. The results demonstrated that intracranial hypertension increased the apoptosis rate, caspase-3 levels and proliferating cell nuclear antigen (PCNA) in the hippocampus, hypothalamus, pituitary gland and showed a consistent rate of apoptosis within each group. The apoptosis rates of hippocampus, hypothalamus and pituitary gland were further increased when intracranial pressure (ICP) at 24 hour (h) were still increased. The change rates of apoptosis in hypothalamus and pituitary gland were significantly higher than hippocampus. Moreover, the stress caused by surgery may be a crucial factor in apoptosis. To confirm stress leads to apoptosis in the hypothalamus and pituitary gland, we used rabbits to establish a standard stress model. The results confirmed that stress leads to apoptosis of neuroendocrine cells in the hypothalamus and pituitary gland, moreover, the higher the stress intensity, the higher the apoptosis rate in the hypothalamus and pituitary gland.

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“…It is used to measure oxygen delivery to brain parenchyma in animal models [111,113,115,133,135,[142][143][144][145][146][147][148][149][150][151]. The utility in traumatic brain injury and severe uncontrolled haemorrhage with short delay prehospital resuscitation was examined in a swine model [152].…”

Section: Animalmentioning

confidence: 99%

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Lang

Jaeger²

2013

TOCCMJ

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This review has been compiled to assess publications related to the clinical application of direct cerebral tissue oxygenation (pbtO2) monitoring published in international, peer-reviewed scientific journals, or major meeting reports published as journal supplements. Its goal was to extract relevant, i.e. positive and negative, information on indications, clinical application, safety issues and impact on clinical situations, as well as treatment strategies in neurosurgery, neurosurgical anaesthesiology, neurosurgical intensive care, neurology, and related specialties. For completeness' sake it also presents related basic science research and case reports. This review is an update of its previous edition published elsewhere in 2007. This review reflects publications from 2004 to 2012. Only relevant publications prior to 2004, which explicitly addressed or systematically examined the above issues, are included in this review and are listed in the reference section. Based on 349 citations it is the most comprehensive review available on direct cerebral oxygen monitoring to this date.Keywords: Review, cerebral oxygenation, raumedic, licox, neurotrend, cerebral partial pressure of oxygen, brain tissue oxygenation. METHODSThis review is based on a systematic "Medline" literature search using the following search terms: licox, neurotrend, neurovent, raumedic, brain tissue oxygen, brain tissue oxygenation, cerebral oxygenation, cerebral tissue oxygen, cerebral partial pressure of oxygen, btO2, ptiO2, pti(O)2, ptiO(2), pbrO2, PBr(O2), P(bt)O(2), P(br)O(2), PbrO(2), BTpO2, tP(O2), PbO2, PbtO2, Pbto, PbtO(2).Only few publications were not retrieved using this technique. They were, however, identified through personal communication with scientists in the field, meeting proceedings and reviewer assignments. This strategy provided sufficient certainty that relevant papers have not been missed. Unpublished meeting abstracts and published conference proceedings were excluded for this review expect for few which provided comparative studies between different probes. To address relevant matters, related to specific pbtO2 issues, selected non-peer reviewed papers published in supplements were also used only when no other peer-reviewed information was available. RESULTSThis review is based on a previous review [1]. It is currently based on 349 papers, 274 more papers compared to its previous version in 2007, which warrants the update.

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A new reproducible model of an epidural mass lesion in rodents. Part I: Characterization by neurophysiological monitoring, magnetic resonance imaging, and histopathological analysis

Abstract: This novel model of an epidural mass lesion in rodents closely resembles the process observed in humans. Evaluation of pathophysiological and morphological changes was feasible by using neurophysiological monitoring and MR imaging.

Cited by 24 publications

References 67 publications

Comparison of different intravascular thread occlusion models for experimental stroke in rats

Comparison of different intravascular thread occlusion models for experimental stroke in rats

Assessment of the role of intracranial hypertension and stress on hippocampal cell apoptosis and hypothalamic-pituitary dysfunction after TBI

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

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