A new response-adaptive design for continuous treatment responses for phase III clinical trials

Bandyopadhyay, Uttam; Biswas, Atanu; Bhattacharya, Rahul

doi:10.1016/j.jspi.2011.01.006

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Cited by 3 publications

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“…They 25 also provided a self-weighted version, where α is determined sequentially depending on the current proportional treatment imbalance together with the results of a detailed simulation for responses without any finite moments. Along the same line of thinking, the authors provided a variation of the above allocation 26 in a very recent work by replacing P (| X 11 − X 12 | > | X 21 − X 22 |) by P ( X 11 2 > X 21 2 ) . …”

Section: General Allocation Designsmentioning

confidence: 99%

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Response-adaptive designs for continuous treatment responses in phase III clinical trials: A review

Biswas

Bhattacharya

2012

Stat Methods Med Res

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A variety of response-adaptive randomization procedures have been proposed in literature assuming binary outcomes. However, the list is not so long for continuous outcomes though many real clinical trials deal with continuous treatment responses. In this paper, we attempt to explore the available procedures together with a comparison of their performances. Some real-life adaptive trial is also reviewed.

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