Strength parameters of the host rock is of paramount importance for modelling the behaviors of underground disposal repository of high-level radioactive waste (HLW). Mobilization of strength parameters should be studied for a better understanding and modelling on the mechanical behaviors of the surrounding rock, considering the effect of temperature induced by the nuclear waste. The granite samples cored from NRG01 borehole in Alxa candidate area in China for HLW disposal are treated by different temperatures (T = 20 °C, 100 °C and 200 °C), and then are used to carry out a series of uniaxial and tri-axial compression experiments under various confining pressures (σ3 = 0, 5, 10, 20, and 30 MPa) in this study. With the recorded axial stress—axial strain and axial stress—lateral strain curves, mobilization of both Mohr-Coulomb and Hoek-Brown strength parameters are analyzed with the increasing plastic shear strain. It has been found that NRG01 granite samples show generally similar cohesion weakening and friction strengthening behaviors, as well as the non-simultaneous mobilization of Hoek-Brown strength parameters (mb and s), under the effect of various treatment temperatures. Furthermore, the samples treated by higher temperatures show lower initial values of cohesion, but their initial friction angle and mb values are relatively higher. This should be mainly owing to the thermally induced cracks in the samples. This study should be helpful for a better modelling on the mechanical behaviors of NRG01 granite samples as the host rock of a possible HLW disposal repository.