The Loess Plateau is one of the most fragile areas in the world, where the problem of soil erosion is particularly prominent. The spatial and temporal variation characteristics and mechanisms of soil erosion in this region have always been hot topics for researchers. In this study, Revised Universal Soil Loss Equation (RUSLE) is used to estimate the soil erosion modulus of the Loess Plateau from 2000 to 2015, the dynamic characteristics of its temporal and spatial variations and driving mechanisms are determined, and meteorological data are combined with remote sensing data to quantitatively calculate the contribution rate of human activities. The results show that from 2000 to 2015, the soil erosion modulus of the Loess Plateau had a downward trend as a whole, with a rate of −0.6408 t/ha/a, but the downward trend gradually slowed down. Precipitation mainly resulted in changes in the soil erosion modulus in the northwestern part of the Loess Plateau, where a significant positive correlation was seen. Meanwhile, the Vegetation Fractional Coverage (VFC) mainly affected the southeastern part, where a significant negative correlation was measured. The human-activity contribution rate was −1.0774 on the Loess Plateau, which means human activities effectively reduced the soil erosion modulus while climate change promoted soil erosion combined with the result of the analysis of variance (ANOVA). “Hilly and gully regions” and “Gully region of Loess Plateau” as the main implementation areas of ecological projects, human activities had contribution rate of 0.5513 and 0.7805 toward the declining of soil erosion, respectively. Interestingly, the spatial differentiation characteristic of the soil erosion driving mechanisms and human contribution rates on the Loess Plateau showed the same boundary line from northeast to southwest, which was well explained by the 400-mm isohyetal line and Hu’s Line. This boundary can guide the geographical layout of the ecological management projects and urban development spaces on the Loess Plateau.