A New Sesquiterpene from the Fruits of Daucus carota L.

Fu, Hongwei; Zhang, Lin; Tao, Yi; Tian, Jingkui

doi:10.3390/molecules14082862

Cited by 15 publications

(12 citation statements)

References 18 publications

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“…The chemical composition of the Daucus carota oil, extracted from different parts of the plant, consists mainly of phenylpropanoids, monoterpenes, sesquiterpenes and phenols in addition to polyphenols which include flavonoids (Gonny et al, 2004;Staniszewska et al, 2005;Rossi et al, 2007;Maxia et al, 2009;Wei Fu et al, 2009, 2010. A study on the dichloromethane-methanol extract of the flower of wild carrot from Turkey, using the 1,1-diphenyl-2-picryl hydrazyl (DPPH) method, revealed significant antioxidant activity (Akgul et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant and Anticancer Effects of Wild Carrot Oil Extract

Shebaby

El‐Sibai

Smith

et al. 2012

Phytotherapy Research

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Daucus carota L. ssp. carota (Apiacea) is used in traditional medicine in Lebanon and in different regions throughout the world. The present study investigates the in vitro anticancer activities of Daucus carota oil extract (DCOE) on four human cancer cell lines as well as its in vitro antioxidant activity. DCOE was extracted from the dried umbels with 50:50 acetone-methanol. The oil extract was analyzed by gas chromatography-mass spectrometry and screened for its antioxidant properties in vitro using 1,1-diphenyl-2-picryl hydrazyl free radical scavenging assay (DPPH), ferrous ion chelating assay (FIC) and the ferric reducing antioxidant power assay (FRAP). The anticancer activity of the oil extract against human colon (HT-29, Caco-2) and breast (MCF-7, MDA-MB-231) cancer cell lines was evaluated using the trypan blue exclusion method and the WST-1 cell proliferation assay. DCOE exhibited antioxidant activity in all assays used. The FRAP value was 164 ± 5.5 µmol FeSO4 /g, and the IC50 values for DPPH and FIC assays were 2.1 ± 0.03 mg/ml and 0.43 ± 0.02 mg/ml, respectively. Also, DCOE demonstrated a significant increase in cell death and decrease in cell proliferation. The effect of DCOE on the cell lines exhibited time and dose-dependent responses. The present study established that DCOE possesses both antioxidant and promising anticancer activities.

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Section: Introductionmentioning

confidence: 99%

The Antioxidant and Anticancer Effects of Wild Carrot Oil Extract

Shebaby

El‐Sibai

Smith

et al. 2012

Phytotherapy Research

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“…Phytochemical investigation of the fruits of Daucus carota resulted in the isolation of a new sesquiterpene named as daucucarotol. It was the first example for a natural eudesmane sesquiterpene with a hydroxymethyl group located at a methine carbon rater than a usual quaternary carbon in the two fused six-membered ring systems [87]. Daucane-type sesquiterpenes such as as trans-dauc-8-ene-4b-ol, trans-dauca-8,11-diene, dauca-5,8-diene, acora-4,9-diene, acora-4,10-diene, carotol, daucol and daucucarotol were isolated from Daucus carota [78,[87][88][89].…”

mentioning

confidence: 99%

“…It was the first example for a natural eudesmane sesquiterpene with a hydroxymethyl group located at a methine carbon rater than a usual quaternary carbon in the two fused six-membered ring systems [87]. Daucane-type sesquiterpenes such as as trans-dauc-8-ene-4b-ol, trans-dauca-8,11-diene, dauca-5,8-diene, acora-4,9-diene, acora-4,10-diene, carotol, daucol and daucucarotol were isolated from Daucus carota [78,[87][88][89]. Ahmed et al, isolated four sesquiterpenes daucane esters, one polyacetylene, one sesquiterpene coumarin, and sitosterol glucoside from the roots of the wild Daucus carota ssp carota [90].Extracts of fresh roots and foliage of the garden carrot (Daucus carota) were analyzed for linear furocoumarins (psoralens) compared with standard psoralen, xanthotoxin, bergapten, isopimpinellin, heraclenin, and oxypeucedanin.…”

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confidence: 99%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, chlorogenic acid, flavonoids, phenols, essential oil, terpenoid and coumarin. The nutritional analysis of carrot juice showed that the juice contained: protein 1.067 ± 0.058%, crude fat 0.367 ± 0.089%, crude fibre 1.167 ± 0.153%, carbohydrates 6.100 ± 0.346%, many vitamins and minerals. The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastro-protective, nephro-protective, hepato-protective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. The current review highlights the chemical constituents, nutritional and pharmacological effects of Daucus carota.

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“…These spectral features were closely related to those of daucucarotol [15], except for a tertiary methyl signal in 2 instead of an oxygenated methylene signal in daucucarotol. The HMBC spectrum of 2 displayed cross-peaks from the doublet methyl signal at  H 0.85 to C-1, C-2, and C-10, which suggested that the doublet methyl group located at C-1.…”

Section: Extraction and Isolationmentioning

confidence: 63%

New terpenoids from the roots of Jatropha curcas

Yang

Liu

et al. 2013

Chin. Sci. Bull.

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Two new sesquiterpenoids, (1S,2R)-dihydroxycycloax-4(15)-ene (1), 14-dehydroxyl daucucarotol (2), and one new rhamnofalane diterpenoid, 2-hydroxy-3-dehydroxycaniojane (3), together with two known compounds, curcusone D (4) and curcusone C (5), were isolated from the roots of Jatropha curcas. The chemical structures of these compounds were established by chemical methods and extensive 1D-and 2D-NMR spectroscopic data analyses. Jatropha curcas, sesquiterpenoids, diterpenoidCitation:

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A New Sesquiterpene from the Fruits of Daucus carota L.

Cited by 15 publications

References 18 publications

The Antioxidant and Anticancer Effects of Wild Carrot Oil Extract

The Antioxidant and Anticancer Effects of Wild Carrot Oil Extract

Nutritional and therapeutic importance of Daucus carota- A review

New terpenoids from the roots of Jatropha curcas

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