A New Sesquiterpene Glycoside from the Aerial Parts of Saussurea triangulata

Min, Yang; Kim, Sung Min; Lee, Kyu Ha; Kim, Ki‐Hyun; Lee, Kang Ro

doi:10.3390/12102270

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…The known compounds were confirmed to be staphylionoside F ( 2 ), 8 dehydrovomifoliol ( 3 ), 9 icariside B1 ( 4 ), 10 6 S ,9 S ‐roseoside ( 5 ), 11 6 S ,9 R ‐roseoside ( 6 ), 11 amarantholidol A glycoside ( 7 ), 12 and calendin ( 2 ) 13 by comparison their physical data (1D NMR) with the previous reported (including CD) data.…”

Section: Resultsmentioning

confidence: 79%

Megastigmanes and other constituents from Achyranthes aspera

Thi Tuyet Lan,

Mai,

Thi Mai Anh

et al. 2024

Vietnam Journal of Chemistry

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A new megastigmane glycoside, (3S,5R,6R,9S)‐6,9‐epoxiionane‐3,5‐diol 3‐O‐β‐primeveroside (1) together with 7 compounds (2–8) were isolated from Achyranthes aspera L. The chemical structures were elucidated through 1D‐, 2D‐ NMR, and HR‐ESI‐MS experiment. The absolute configuration of 1 was determined using combination of the experimental and theoretical calculation of CD spectra. Compounds 2 and 7 were reported for the first time from the genus Achyranthes.

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Section: Resultsmentioning

confidence: 79%

Megastigmanes and other constituents from Achyranthes aspera

Thi Tuyet Lan,

Mai,

Thi Mai Anh

et al. 2024

Vietnam Journal of Chemistry

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“…Yang et al reported the isolation of several sesquiterpene glycoside from the aerial parts of S. triangulata. [6]. However, the components responsible for the neuroprotective effects of S. triangulata still remain unidentified.…”

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confidence: 99%

Quinic acid derivatives from Saussurea triangulata attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells

Chung

Kim

Park

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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The leaves of Saussurea triangulata (Compositae) have been eaten with rice as a wrapping vegetable for preventing neuroaging. However, the components responsible for the neuroprotective effects of S. triangulata still remain unidentified. In the process of investigating the neuroprotective activity of S. triangulata, we found that a methanol extract of S. triangulata exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells. Three quinic acid derivatives were isolated from the n-BuOH fraction of S. triangulata. Among these three quinic acid derivatives, methyl 5-caffeoylquinic acid (3) exhibited significant neuroprotective activities against glutamate-induced toxicity exhibiting cell viability of about 50%, at concentrations ranging from 0.1 mM to 10 mM. Therefore, the neuroprotective effect of S. triangulata might be due to the inhibition of glutamate-induced toxicity by the quinic acid derivatives from S. triangulata.

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“…Previous studies on this plant disclosed the presence of flavonoids, polyphenolic acids, and diterpenes [1 -6]. Our phytochemical investigation on the 50% EtOH extract of the title plant led to the isolation of 18 compounds, comprising clerodendranthuside B (1), a new 8b-hydroxyisopimarene-type diterpenoid glucoside, and clerodendranthuside C (2), a new rearranged abietanoid-type diterpenoid glucoside, along with sixteen known compounds including four lignans, i.e., syringaresinol [7], syringaresinol 4'-O-bglucopyranoside [8], 1-hydroxysyringaresinol [9], and 8-hydroxypinoresinol [10], five miscellaneous phenylpropanoids, i.e., 2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl)biphenyl [11], albibrissinoside B [12], glypentoside C [13], ethyl caffeate [14], and (2S,E)-N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]ferulamide [15], two flavonoids, i.e., prunin [16] and (2S)-naringenin [17], one sesquiterpenoid glycoside, amarantholidol A glycoside [18], two triterpenoid glycosides, i.e., arjunglucoside I [19] and arjungenin-23,28-bis-O-glucopyranoside [20], one megastigmane, i.e., vomifoliol [21], and one anthraquinone, i.e., emodin [22]. Except for prunin, (2S)-naringenin, and vomifoliol, the above other compounds were reported from this genus for the first time.…”

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confidence: 99%

Two New Diterpenoid Glucosides from Clerodendrathus spicatus

Chen

Tan

et al. 2009

Helvetica Chimica Acta

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Two new diterpenoid glucosides, clerodendranthusides B and C (1 and 2, resp.), together with 16 known compounds, comprising four lignans, five miscellaneous phenylpropanoids, two flavonoids, one sesquiterpenoid glycoside, two triterpenoid glycosides, one megastigmane, as well as one anthraquinone, were isolated from the 50% EtOH extract of the whole plants of Clerodendrathus spicatus. Their structures were elucidated by chemical and spectroscopic methods. , vomifoliol [21], and one anthraquinone, i.e., emodin [22]. Except for prunin, (2S)-naringenin, and vomifoliol, the above other compounds were reported from this genus for the first time. In this article, we report the isolation and structural elucidation of compounds 1 and 2 (Fig. 1).

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A New Sesquiterpene Glycoside from the Aerial Parts of Saussurea triangulata

Cited by 10 publications

References 13 publications

Megastigmanes and other constituents from Achyranthes aspera

Megastigmanes and other constituents from Achyranthes aspera

Quinic acid derivatives from Saussurea triangulata attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells

Two New Diterpenoid Glucosides from Clerodendrathus spicatus

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