A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform

Abstract

The NIR light‐induced imaging‐guided cancer therapy is a promising route in the targeting cancer therapy field. However, up to now, the existing single‐modality light‐induced imaging effects are not enough to meet the higher diagnosis requirement. Thus, the multifunctional cancer therapy platform with multimode light‐induced imaging effects is highly desirable. In this work, captopril stabilized‐Au nanoclusters Au25(Capt)18−(Au25) are assembled into the mesoporous silica shell coating outside of Nd3+‐sensitized upconversion nanoparticles (UCNPs) for the first time. The newly formed Au25 shell exhibits considerable photothermal effects, bringing about the photothermal imaging and photoacoustic imaging properties, which couple with the upconversion luminescence imaging. More importantly, the three light‐induced imaging effects can be simultaneously achieved by exciting with a single NIR light (808 nm), which is also the triggering factor for the photothermal and photodynamic cancer therapy. Besides, the nanoparticles can also present the magnetic resonance and computer tomography imaging effects due to the Gd3+ and Yb3+ ions in the UCNPs. Furthermore, due to the photodynamic and the photothermal effects, the nanoparticles possess efficient in vivo tumor growth inhibition under the single irradiation of 808 nm light. The multifunctional cancer therapy platform with multimode imaging effects realizes a true sense of light‐induced imaging‐guided cancer therapy.

Advanced Functional Nanomaterials for Theranostics

“…[231] Several photosensitizers have been combined with UCNPs for photodynamic therapy such as Rose Bengal (RB), [212, 213] Chlorin e6, [218, 232] a trans-platinum (IV) photosensitizer, [233, 234] and titanium dioxide [235–240] . In addition, by assembling UCNPs with gold-based materials, photothermal cancer therapy applications are possible [202, 228] .…”

Multifunctional Photosensitizer Grafted on Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nanographene Oxide for Cancer-Targeted Near-Infrared Imaging and Synergistic Phototherapy

“…20 This synergistic PDT/PTT treatment triggered by a single light could facilitate continuous and simultaneous cancer phototherapy and has attracted considerable research interest. [36][37][38][39][40] Inspired by the multifunctional properties of IR-808 and NGO, in this work, we demonstrate novel covalent conjugation of IR-808 to NGO with the aim to achieve highly efficient cancer phototherapy with minimal side effects by combining PDT and PTT treatment 5 HyClone. (Thermo Scientific, USA).…”

A General In Situ Growth Strategy of Designing Theranostic NaLnF4@Cu2−xS Nanoplatform for In Vivo NIR‐II Optical Imaging Beyond 1500 nm and Photothermal Therapy

“…[1][2][3][4][5][6][7][8][9][10][11] Among multiple imaging modalities, fluorescencebased optical imaging as a non-invasive technique has drawn immense attention in the imaging-guided therapy platform due to the advantages of high accuracy, highsensitivity, absence of high-energy radiation, and fast feedback. [1][2][3][4][5][6][7][8][9][10][11] Among multiple imaging modalities, fluorescencebased optical imaging as a non-invasive technique has drawn immense attention in the imaging-guided therapy platform due to the advantages of high accuracy, highsensitivity, absence of high-energy radiation, and fast feedback.…”