This paper investigates the performance of Asymmetric Multilevel Inverter (AMLI) with reduced number of switches for fuel cell applications. The proposed topology generates fifteen-level output with improved spectral quality of the output. Moreover, a novel hybrid modulation strategy based on Variable Amplitude Phase Opposition Disposition (VAPOD) technique is implemented. The proposed topology is powered by PEM fuel cell source which is modeled in MATLAB. The performance parameters such as Total Harmonic Distortion (THD), Weighted THD (WTHD), Harmonic Spread Factor (HSF) and Distortion Factor (DF) are computed to verify the performance of the proposed topology. Circuit simulation studies are carried out in MATLAB/SIMULINK software and the results are verified.