2005
DOI: 10.1007/s00705-005-0601-2
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A new small temperate DNA phage BcP15 isolated from Burkholderia cepacia DR11

Abstract: A Burkholderia cepacia DR11 strain was isolated during the survey of microorganisms from coastal water of deltaic Sunderbans. This strain always released temperate phage BcP15 into culture supernatant. UV irradiation of the strain also induced phage induction. The phage titer was 2.3 x 10(8). New temperate phage BcP15 has unusual structure. It has a hexagonal head, 65 nm in diameter and a tail 200 nm long, attached with single thick wavy tail fiber (424-705 nm). Phage DNA is double stranded 11.9 kb long. South… Show more

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Cited by 6 publications
(3 citation statements)
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“…Specialized transduction by a Burkholderia phage of a phenotype that might be significant to host pathology has been demonstrated in only one case. Phage BcP15, produced by B. cepacia DR11, appears to transmit co-trimoxazole, trimethoprim and erythromycin resistance not only to Burkholderia but also to Shigella flexneri KN1925 [26,27]. A classic mechanism by which phage can transmit virulence factors is through generalized transduction.…”
Section: Phages Of Burkholderia: Any Virulence Factors?mentioning
confidence: 99%
“…Specialized transduction by a Burkholderia phage of a phenotype that might be significant to host pathology has been demonstrated in only one case. Phage BcP15, produced by B. cepacia DR11, appears to transmit co-trimoxazole, trimethoprim and erythromycin resistance not only to Burkholderia but also to Shigella flexneri KN1925 [26,27]. A classic mechanism by which phage can transmit virulence factors is through generalized transduction.…”
Section: Phages Of Burkholderia: Any Virulence Factors?mentioning
confidence: 99%
“…Lysogenic conversion is not well studied in Burkholderia species, and when done so typically examines change in virulence [ 78 , 104 ]. Two significant reasons for the paucity of studies in this area are that many of the characterized Burkholderia phages have been isolated from lysogens and therefore lack a wildtype strain for comparison [ 40 , 74 , 80 , 106 , 107 , 108 , 109 ], and/or attempts to create stable lysogens in other strains were unsuccessful [ 62 , 63 ]. A third reason is that most phage characterization studies are done with intent of using the phages for therapy and therefore favour the idea of removing lysogeny genes as opposed to studying lysogenic conversion [ 80 , 104 ].…”
Section: Resultsmentioning
confidence: 99%
“…BcP15, a temperate siphovirus of the environmental isolate B. cepacia DR11, was found to infect only Shigella flexneri Pl-35 (a plasmid-cured isolate of S. flexneri NK1925; Hens et al, 2005, 2006). Putative Pl-35 lysogens were resistant to co-trimoxazole, trimethoprim, and erythromycin, and it was suggested that the integrated BcP15 DNA was responsible for this phenotype (Hens et al, 2006).…”
Section: Phage Therapy In the Bccmentioning
confidence: 99%