Twenty‐five years after the last major revision, the results of a molecular phylogenetic analysis have necessitated a re‐classification of the Disinae (Orchidoideae, Orchidaceae). The small genus Schizodium, endemic to the Cape Floristic Region, is deeply embedded in the genus Disa and its generic status can thus no longer be maintained. We propose a monogeneric subtribe Disinae and a subdivision of Disa into eighteen sections and one nothosection. Excluding the latter, the sections are monophyletic, well‐supported, morphologically distinguishable and are delimited to maximize the congruence with the previous classification. All 180 described and one undescribed species, as well as four named, natural hybrids are enumerated and assigned to sections and the nothosection.