This paper studies the performance of the energy-based sensing procedure in the presence of multipath fading and shadowing effects in terms of its average probability of detection (APD), average receiver operating characteristic (AROC) and the area under the AROC curve (AUC). A new generalization for the class of the fading channel moment generating functions (MGFs) (i.e., factorized power type (FPT) MGF) was proposed and applied for the construction of the unified framework for the analytical treatment of the formulated problem. The contiguity of the proposed model with the existing classical ones (Rayleigh, Nakagami-m, Hoyt, η−μ, κ−μ shadowed and Mixture-Gamma) was demonstrated. Within the assumed MGF representation, the novel closed-form solutions and computationally efficient approximation for APD and AUC are derived. The obtained general expressions were then applied for derivation of the new results for the recent generalized fading channel models: Fluctuating Beckmann and Beaulieu-Xie shadowed. For each of the models, high-SNR asymptotic expressions were obtained. Lastly, numeric simulation was performed to verify the correctness of the derived results, to establish the dependencies of the sensing performance quality from the channel parameters and to identify the specific ranges of their asymptotic behavior.