A New Stilbene from the Root of <i>Cassia sieberiana</i> D.C. (Fabaceae)

Jibril, Saidu; Sirat, Hasnah Mohd; Basar, Norazah

doi:10.1177/1934578x1701200723

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…According to the available literature, phenolic compounds or their derivatives were reported to exhibit antioxidant activities [ 27 ]. Researchers demonstrated that chrysophanol has no activity against DPPH and ABTS + radicals [ 28 ]. However, other researchers showed that the compound had a scavenging effect on DPPH radical (IC 50 value of 26.56 μ g/mL).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial and Antioxidant Compounds from the Root Extract of Aloe debrana

Getahun,

Das,

Sil

et al. 2024

Evidence-Based Complementary and Alternative Medicine

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This study was conducted to isolate and identify the chemical compounds from the roots of Aloe debrana (L.) and evaluate their antioxidant and antibacterial activities. From the acetone (99.5%) extract of the roots of this plant, four anthraquinones, such as chrysophanol (1), asphodeline (2), aloesaponarin I (5), and laccaic acid D-methyl ester (6), and a new catechol derivative, 5-allyl-3-methoxybenzene-1,2-diol (3), were isolated and elucidated by different chromatographic and spectroscopic methods together with linoleic acid (4), respectively. Compounds 2, 3, and 4 were reported here for the first time from this plant and compound 3 from the genus Aloe. The compounds were evaluated for their antioxidant activity using H2O2 and DPPH assays and bactericidal activity against S. aureus and E. coli. Compounds 3 and 6 showed highest antioxidant activities with IC50 values of 19.38 ± 0.64 and 32.81 ± 0.78 μg/mL in DPPH, and 28.52 ± 1.08 and 27.31 ± 1.46 μg/mL in H2O2, respectively. The isolated compounds also demonstrated considerable activity towards S. aureus. Among these compounds, compound 3 exhibited the highest activity (91.20 ± 0.12% and 9.14 ± 0.93 mm at 1.0 mg/mL) against this bacterium. The overall results suggest that the isolated compounds may be considered as potential sources of the bioactive agents to be used in the pharmacological, food, and other industries. Moreover, their high sensitivity against S. aureus may also support the use of A. debrana plant in the traditional medicine to treat wounds. Therefore, the isolated compounds are responsible for medicinal properties of this plant.

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Section: Resultsmentioning

confidence: 99%

Antibacterial and Antioxidant Compounds from the Root Extract of Aloe debrana

Getahun,

Das,

Sil

et al. 2024

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…263,264 The results on its hydrogenated derivative, 2,3-dihydroamentoflavone (165), also suggest a similar pattern. 263 In a study by Ho et al, 252 the inhibitory activity of procyanidin C1 (173), procyanidin B2 (174), and procyanidin B5 (175) were also reported. In this study, all these three oligomeric flavonoids outperformed acarbose in the both two α-glucosidase and α-amylase inhibition assay, with the IC50 values varied below 10 µM.…”

Section: Isoflavonoidmentioning

confidence: 95%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

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Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes. Six scientific databases were queried up until August 21, 2022, for in vitro studies reporting the IC50 results of purified flavonoids on α-amylase or α-glucosidase, along with the respective data of acarbose control. A total of 339 articles were assessed as eligible and subjected to the data extraction process, resulting in 1643 retrieved structures, 177 compounds of which showed both inhibitions against α-amylase and α-glucosidase. Quality assessment was conducted following a modified CONSORT checklist. The structureactivity relationships revealed that a double bond C2=C3 and a keto group C4=O is essential for simultaneous inhibition. The hydroxyl group at C3 is favourable for α-glucosidase inhibition but detrimental to the effect against α-amylase. Further notable features which affect α-glucosidase and α-amylase inhibition were also discussed. Several limitations were considered, including the inconsistency among included studies, language restriction, and the contemporaneity of the review. In conclusion, the systematic review has summarized some crucial findings in the investigation of flavonoids as dual-target inhibitors against α-glucosidase and α-amylase and proposed several orientations for future research.

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“…263,264 The results on 2,3-dihydroamentoflavone (165) also suggest a similar pattern. 263 In a study by Ho et al, 251 the inhibitory activity of procyanidin C1 (173), procyanidin B2 (174), and procyanidin B5 (175) were also reported. In this study, all these three oligomeric flavonoids outperformed acarbose in the both two α-glucosidase and α-amylase inhibition assay, with the IC50 values varied below 10 µM.…”

Section: Oligomeric Flavonoidsmentioning

confidence: 97%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

View full text Add to dashboard Cite

Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes. Six scientific databases were queried up until August 21, 2022, for in vitro studies reporting the IC50 results of purified flavonoids on α-amylase or α-glucosidase, along with the respective data of acarbose control. A total of 339 articles were assessed as eligible and subjected to the data extraction process, resulting in 1643 retrieved flavonoid structures. Chemical structures were then rigorously standardized and curated to 974 unique compounds, in which 177 flavonoids showed both inhibitions against α-amylase and α-glucosidase. Quality assessment was conducted following a modified CONSORT checklist. The structure-activity relationships revealed that a double bond C2=C3 and a keto group C4=O is essential for simultaneous inhibition. The hydroxyl group at C3 is favourable for α-glucosidase inhibition but detrimental to the effect against α-amylase. Further notable features which affect α-glucosidase and α-amylase inhibition were also discussed. Several limitations were considered, including the inconsistency among included studies, language restriction, and the contemporaneity of the review. In conclusion, the systematic review has summarized some crucial findings in the investigation of flavonoids as dual-target inhibitors against α-glucosidase and α-amylase and proposed several orientations for future research.

show abstract

A New Stilbene from the Root of Cassia sieberiana D.C. (Fabaceae)

Cited by 6 publications

References 15 publications

Antibacterial and Antioxidant Compounds from the Root Extract of Aloe debrana

Antibacterial and Antioxidant Compounds from the Root Extract of Aloe debrana

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

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