A new strategy for durable control of late blight in potato by a single soil application of an oxathiapiprolin mixture in early season

Abstract

Root treatment with oxathiapiprolin, benthiavalicarb or their mixture Zorvec-Endavia [ZE (3+7, w/w)] was shown to provide prolonged systemic protection against foliar oomycete pathogens attacking cucumber, tomato and basil. Here we report that these fungicides can effectively protect potato plants against late blight when applied to the soil in which such potato plants are grown. In two field experiments, performed in 2019 and 2020, potato plants grown in 64 L containers were treated with a soil drench of oxathiapiprolin, benthiavalicarb or ZE at 12.5, 25 or 50 mg ai/five plants in a container. Artificial inoculations with Phytophthora infestans revealed that such treated plants were protected against late blight in a dose-dependent manner all along the season. Interestingly, oxathiapiprolin persisted in the treated soil for at least 139 days, providing systemic protection against late blight to the following potato crops grown in that treated soils. Potato plants grown in loess soil in the field were either sprayed or drenched with ZE. Plants treated via the soil were significantly better protected against late blight compared to the plants treated by a spray. The data demonstrate a new strategy for season-long protection of potato against late blight by a single soil application of ZE. The systemic nature of oxathiapiprolin and benthiavalicarb composing ZE assures the translocation to the foliage of two fungicides with different modes of action. This shall minimize the risk of developing resistance against either fungicide in the treated crops.

Optimal Resistance Management for Mixtures of High-Risk Fungicides: Robustness to the Initial Frequency of Resistance and Pathogen Sexual Reproduction

“…Future work may consider extending these ideas to such pathosystems e.g. grapevine powdery mildew (Elderfield et al, 2018) or potato blight (Pacilly et al, 2018;Cohen and Rubin, 2020). However, we also note that past research on mixtures containing a high risk fungicide and a low risk fungicide (Elderfield et al, 2018) showed a remarkable consistency of optimal recommendation across pathosystems and model structures, and we have no reason to believe results would differ for other pathosystems.…”

Toxicokinetics of Two Oxathiapiprolin Enantiomers in Rats and Their Stereoselective Interaction with Oxysterol Binding Protein

“…Every year, a large number of pesticides are needed to prevent crop diseases. − Oxathiapiprolin is a piperidinyl thiazole isooxazoline fungicide developed by DuPont Agrochemical Company. It targets oomycetes, such as Phytophthora infestans, Plasmopara halstedii, Peronospora belbahrii, and Phytophthora parasitica . Its structure consists of sequentially arranged oxazole, thiazole, piperidine and pyrazole (four heterocyclic rings), and it affects the metabolism of cholesterol-based compounds by inhibiting oxysterol binding protein (OSBP) to exert a relatively good fungicidal effect. , …”

Uptake, Translocation, and Subcellular Distribution of Oxathiapiprolin and Famoxadone in Tomato Plants (Lycopersicon esculentum Miller)

“…It could also disturb photosynthesis and cause oxidative damage and abnormal energy metabolism in Chlorella vulgaris cells . Since oxathiapiprolin can be used for soil application, there is a high risk to the environment and the possibility of transfer to the food chain through crop absorption. , Besides, oxathiapiprolin often is used in combination with fungicides with different mechanisms of action, such as famoxadone, to effectively delay the generation of resistance. In China, the combination of oxathiapiprolin and famoxadone has been registered to control oomycetes and early blight (fungal disease), garnering widespread attention .…”